The numbers of peripheral regulatory T cells are reduced in patients with psoriatic arthritis and are restored by low-dose interleukin-2

Therapeutic Advances in Chronic Disease
Jia WangXiao-Feng Li

Abstract

Although regulatory T cells (Tregs) play crucial roles in the maintenance of immune hemostasis, the numbers of peripheral Tregs in patients with psoriatic arthritis (PsA) remain unclear. We measured these numbers and the efficacy and safety of low-dose interleukin-2 (IL-2) therapy. We recruited 95 PsA patients, of whom 22 received subcutaneous low-dose IL-2 [0.5 million international units (MIU) per day for 5 days] combined with conventional therapies. The absolute numbers of cells in peripheral CD4+ T cell subsets were measured via modified flow cytometry. Clinical and laboratory indicators were compared before and after treatment. PsA patients had lower peripheral Treg numbers than healthy controls (p < 0.01), correlating significantly and negatively with the levels of disease indicators (p < 0.05). Although low-dose IL-2 significantly increased the Th17 and Treg numbers in PsA patients compared with the baseline values, the Treg numbers rose much more rapidly than those of Th17 cells, re-balancing the Th17 and Treg proportions. Low-dose IL-2 combination therapy rapidly reduced PsA disease activities as indicated by the DAS28 instrument, thus the number of tender joints, visual analog scale pain, physician global assessment, ...Continue Reading

References

Jan 1, 1993·Annual Review of Immunology·Y MinamiT Taniguchi
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki SugiyamaKevin D Cooper
Jul 28, 2006·Arthritis and Rheumatism·William TaylorUNKNOWN CASPAR Study Group
Dec 8, 2007·Annual Review of Immunology·Thomas R Malek
Feb 2, 2008·Arthritis Research & Therapy·Qing Yu ZengNai Zheng Zhang
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Linda A Lieberman, George C Tsokos
Oct 12, 2010·Science Translational Medicine·Wolfgang HueberFranco Di Padova
Jan 27, 2011·The Journal of Small Animal Practice·N T Whitley, M J Day
Apr 7, 2011·Nature Reviews. Rheumatology·Mei Zong, Ingrid E Lundberg
Jan 10, 2012·International Journal of Inflammation·Janelle C Waite, Dimitris Skokos
Feb 22, 2012·Nature Reviews. Immunology·Onur Boyman, Jonathan Sprent
Sep 21, 2013·Nature Immunology·Dalia BurzynDiane Mathis
Nov 30, 2013·Arthritis Research & Therapy·Helen BenhamHill Gaston
Dec 2, 2014·The Journal of Clinical Investigation·Valerie A GerrietsJeffrey C Rathmell
Apr 18, 2015·Nature Reviews. Immunology·David Klatzmann, Abul K Abbas
Feb 4, 2016·Trends in Molecular Medicine·Audrey BeringerPierre Miossec
Oct 21, 2016·The Journal of Pathology·Rafael Leite DantasViktor Wixler
Apr 1, 2017·Current Opinion in Rheumatology·Zijun WangQianjin Lu
Jul 7, 2017·Arthritis Research & Therapy·Agnes SzentpeteryOliver FitzGerald
Sep 27, 2018·Journal of Immunology Research·Sheng-Xiao ZhangXiao-Feng Li

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Citations

Dec 19, 2020·Frontiers in Immunology·Zhussipbek MukhatayevI Caroline Le Poole
Apr 20, 2021·Frontiers in Immunology·Hanna GraßhoffJens Y Humrich
May 18, 2021·Therapeutic Advances in Musculoskeletal Disease·Sheng-Xiao ZhangXiao-Feng Li
Nov 4, 2021·Nature Reviews. Rheumatology·Antonios G A KoliosDavid Klatzmann
Dec 1, 2021·Expert Review of Clinical Immunology·Homa Seyedmirzaei, Nima Rezaei

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Methods Mentioned

BETA
flow cytometry
ESR

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