The O-glycan pathway is associated with in vitro sensitivity to gemcitabine and overall survival from ovarian cancer.

International Journal of Oncology
Nadim Bou ZgheibJohnathan M Lancaster

Abstract

Ovarian cancer (OVCA) is the most lethal gynecological malignancy. The high mortality rate associated with this disease is due in large part to the development of resistance to chemotherapy; however, the biological basis of this remains unclear. Gemcitabine is frequently used for the treatment of patients with platinum-resistant OVCA. We report molecular signaling pathways associated with OVCA response to gemcitabine. Forty-one OVCA cell lines were subjected to gene expression analysis; in parallel, IC50 values for gemcitabine were quantified using CellTiter-Blue viability assays. Pearson's correlation coefficients were calculated for gene expression and gemcitabine IC50 values. The genes associated with gemcitabine sensitivity were subjected to pathway analysis. For the identified pathways, principal component analysis was used to derive pathway signatures and corresponding scores, which represent overall measures of pathway expression. Expression levels of the identified pathways were then evaluated in a series of clinico-genomic datasets from 142 patients with stage III/I...Continue Reading

Citations

Feb 20, 2014·Medicinal Research Reviews·Ahmed H MekkawyDavid L Morris
Jun 24, 2015·Critical Reviews in Oncology/hematology·M P WeenC Ricciardelli
Jun 28, 2014·International Journal of Oncology·Xia LiuFuqiang Yin

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