PMID: 9182999May 1, 1997Paper

The O-specific polysaccharide chain of Campylobacter fetus serotype A lipopolysaccharide is a partially O-acetylated 1,3-linked alpha-D-mannan

European Journal of Biochemistry
S N SenchenkovaA P Moran

Abstract

A polysaccharide fraction liberated from Campylobacter fetus subsp. fetus serotype A lipopolysaccharide by mild acid hydrolysis followed by gel-permeation chromatography contained a partially O-acetylated D-mannan chain, as an O-specific polysaccharide, with a core oligosaccharide attached. The structure of the polysaccharide was studied by O-deacetylation, methylation, and 1H- and 13C-NMR spectroscopy, including computer-assisted analysis of the 13C-NMR spectrum. A structure of -->3)-alpha-D-Manp2Ac-(1--> was established as the structure of the O-specific polysaccharide, the degree of O-acetylation of the mannose residues at position 2 being estimated as 80-90%. As judged by the ratio of mannose to core constituents, the D-mannan chain consists on average of 10-12 monosaccharide units.

References

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Feb 1, 1992·Journal of Bacteriology·L Y YangM J Blaser
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Sep 1, 1994·Infection and Immunity·A P MoranI M Helander
Aug 1, 1996·FEMS Immunology and Medical Microbiology·A P MoranI M Helander

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