The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids

Osteoarthritis and Cartilage
Marienke van MiddelkoopS M A Bierma-Zeinstra

Abstract

To evaluate the efficacy of intra-articular (IA) glucocorticoids for knee or hip osteoarthritis (OA) in specific subgroups of patients with severe pain and inflammatory signs using individual patient data (IPD) from existing trials. Randomized trials evaluating one or more IA glucocorticoid preparation in patients with knee or hip OA, published from 1995 up to June 2012 were selected from the literature. IPD obtained from original trials included patient and disease characteristics and outcomes measured. The primary outcome was pain severity at short-term follow-up (up to 4 weeks). The subgroup factors assessed included severe pain (≥70 points, 0-100 scale) and signs of inflammation (dichotomized in present or not) at baseline. Multilevel regression analyses were applied to estimate the magnitude of the effects in the subgroups with the individuals nested within each study. Seven out of 43 published randomized clinical trials (n = 620) were included. Patients with severe baseline pain had a significantly larger reduction in short-term pain, but not in mid- and long-term pain, compared to those with less severe pain at baseline (Mean Difference 13.91; 95% Confidence Interval 1.50-26.31) when receiving IA glucocorticoid injection...Continue Reading

Associated Clinical Trials

References

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Citations

Dec 22, 2017·Rheumatology·Leticia A Deveza, Richard F Loeser
Nov 4, 2017·Nature Reviews. Rheumatology·Sita M Bierma-Zeinstra, Marienke van Middelkoop
Aug 6, 2019·British Journal of Pharmacology·Imke Rudnik-JansenLaura B Creemers
Nov 12, 2019·Expert Opinion on Drug Metabolism & Toxicology·Win Min OoDavid J Hunter
Apr 3, 2019·The Journal of Rheumatology·Nasimah MaricarTerence W O'Neill
Feb 1, 2020·British Journal of Sports Medicine·Marienke van MiddelkoopSita M A Bierma-Zeinstra
Apr 13, 2018·Der Schmerz·T A Nees, M Schiltenwolf
Jun 24, 2020·World Journal of Orthopedics·Gustavo C de CamposMárcia U de Rezende
Apr 9, 2020·The New England Journal of Medicine·Kim L Bennell, David J Hunter
Nov 29, 2020·Skeletal Radiology·Thanat KanthawangRina Patel
Dec 18, 2020·Acta ortopedica brasileira·MÁrcia UchÔa DE RezendeOlavo Pires DE Camargo
Apr 28, 2021·Journal of Evidence-based Integrative Medicine·Dai SugimotoGianmichel D Corrado

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