The obese growth hormone (GH)-deficient dwarf rat: body fat responses to patterned delivery of GH and insulin-like growth factor-I

Endocrinology
R G ClarkI C Robinson

Abstract

We describe a new animal model of obesity and GH deficiency and report the effects on body fat of administering (GH) and insulin-like growth factor (IGF-I) in the model. Female GH-deficient dwarf rats fed a high-fat diet became obese and insulin-resistant compared with chow-fed controls. They were treated with recombinant human GH (rhGH 100-500 micrograms/day, s.c. for 14 days) by daily injection or minipump infusion with or without rhIGF-I (200 micrograms/day, sc infusion). Injections of rhGH increased body weight; infusions of rhGH caused weight loss. RhIGF-I by itself, or rhIGF-I plus GH injections had little effect, whereas rhGH infusions plus rhIGF-I caused a weight loss equivalent to the weight gained during the high-fat feeding and a decrease in fat pad weight. For some responses (serum IGF-1 and GHBP), the obese rats were GH resistant. Fat was lost from the internal fat pads when obese rats were returned to a chow diet, and injections of rhGH surprisingly attenuated this loss of fat. In obese dwarf rats, the lipolytic effects of rhGH are dose-regime dependent. By itself IGF-I is not insulin-like, but in the presence of GH it has antiinsulin actions causing a powerful net lipolysis. If GH plus IGF-I have similar effects ...Continue Reading

Citations

Dec 3, 2005·The Journal of Clinical Investigation·Katherine E WortleyMark W Sleeman
May 9, 2006·Treatments in Endocrinology·Andreas Jostel, Stephen M Shalet
Feb 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jeffrey S DaviesTimothy Wells
Dec 1, 2002·Nutrition Research Reviews·Yasufumi FuruhataMichio Takahashi
Mar 23, 2004·Endocrinology·Randip K BainsIain C A F Robinson
Aug 5, 1998·The American Journal of Physiology·T J LauterioR Ramirez

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