The obesogen tributyltin induces features of polycystic ovary syndrome (PCOS): a review

Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Eduardo MerloJones B Graceli

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome characterized by abnormal reproductive cycles, irregular ovulation, and hyperandrogenism. This complex disorder has its origins both within and outside the hypothalamic-pituitary-ovarian axis. Cardio-metabolic factors, such as obesity and insulin resistance, contribute to the manifestation of the PCOS phenotype. Polycystic ovary syndrome is one of the most common endocrine disorders among women of reproductive age. Growing evidence suggested an association between reproductive and metabolic features of PCOS and exposure to endocrine-disrupting chemicals (EDC), such as bisphenol A. Further, the environmental obesogen tributyltin (TBT) was shown to induce reproductive, metabolic and cardiovascular abnormalities resembling those found in women and animal models of PCOS. However, the causal link between TBT exposure and PCOS development remains unclear. The objective of this review was to summarize the most recent research findings on the potential association between TBT exposure and development of PCOS-like features in animal models and humans.

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Citations

Nov 13, 2018·Journal of Toxicology and Environmental Health. Part a·Dong Hyun KimByung-Mu Lee
Sep 24, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Mariana Zuccherato BocatoFernando Barbosa
Apr 3, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Isabela V SarmentoJones B Graceli
Oct 6, 2020·Journal of Toxicology and Environmental Health. Part a·Ping Li, Zhi-Hua Li
May 1, 2021·International Journal of Molecular Sciences·Li-Hsuan WangKuo-Hu Chen

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