The observation of cis residues in poly(L-proline) in aqueous solution.

Macromolecules
C C WuL Mandelkern

Abstract

Proton Fourier transform NMR spectra at 270 MHz were obtained for three different molecular weight samples of poly(L-proline) in D2O. A weak, but clearly discernable, resonance at 4.3 ppm was observed in each case with an integrated intensity about 2-3% of the Calpha trans proton resonance. Based on the Torchia-Bovey assignment this resonance is attributed to the Calpha cis proton. The presence of cis residues, even in this small concentration, necessitates a reexamination of the conformational properties of this polymer. Definite conclusions cannot be reached from spectra obtained in organic solvents because of the much smaller separation between the cis and trans resonances.

Citations

Oct 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sören DooseMarkus Sauer
Jan 22, 2013·Biopolymers·Wolfgang J SchreierWolfgang Zinth
Jan 1, 1982·International Journal of Peptide and Protein Research·N Helbecque, M H Loucheux-Lefebvre
Sep 1, 2006·The Journal of Physical Chemistry. B·Young Kee KangHae Sook Park

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