Mar 30, 2016

The Occipital Place Area Is Causally Involved in Representing Environmental Boundaries during Navigation

Current Biology : CB
Joshua B JulianRussell A Epstein


Thirty years of research suggests that environmental boundaries-e.g., the walls of an experimental chamber or room-exert powerful influence on navigational behavior, often to the exclusion of other cues [1-9]. Consistent with this behavioral work, neurons in brain structures that instantiate spatial memory often exhibit firing fields that are strongly controlled by environmental boundaries [10-15]. Despite the clear importance of environmental boundaries for spatial coding, however, a brain region that mediates the perception of boundary information has not yet been identified. We hypothesized that the occipital place area (OPA), a scene-selective region located near the transverse occipital sulcus [16], might provide this perceptual source by extracting boundary information from visual scenes during navigation. To test this idea, we used transcranial magnetic stimulation (TMS) to interrupt processing in the OPA while subjects performed a virtual-reality memory task that required them to learn the spatial locations of test objects that were either fixed in place relative to the boundary of the environment or moved in tandem with a landmark object. Consistent with our prediction, we found that TMS to the right OPA impaired spati...Continue Reading

  • References49
  • Citations12


  • References49
  • Citations12


Mentioned in this Paper

Spatial Memory
Neuro-Oncological Ventral Antigen 2
Mediator of RNA Polymerase II Transcription Subunit 12
Occipital Lobe
Virtual Reality, Educational
TRIP6 gene
Spatial Distribution

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Signaling in Adult Neurogenesis

Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.

Psychiatric Chronotherapy

Psychiatric Chronotherapy considers the circadian rhythm as a major factor for optimizing therapeutic efficacy of psychiatric interventions. Discover the latest research on Psychiatric Chronotherapy here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Daniel D DilksNancy Kanwisher
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Daniel D DilksNancy Kanwisher
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Caitlin R Mullin, Jennifer K E Steeves
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sebastian GuderianFaraneh Vargha-Khadem
The Australian and New Zealand Journal of Psychiatry
A Pascual-Leone, H Pridmore
© 2020 Meta ULC. All rights reserved