PMID: 41788Nov 1, 1979

The occurrence of a distinct high molecular weight form of serum non-suppressible insulin-like activity

Molecular and Cellular Endocrinology
R C FranklinA C Herington

Abstract

Gel filtration of acromegalic or normal serum at acid pH gave two distinct species of non-suppressible insulin-like activity (NSILA), one of high MW and the other of low MW (approximately 7000 daltons). The acid-stable high MW form remained high MW on rechromatography in acid. Gel filtration of serum at neutral pH however, gave only high MW activity, which remained high MW when rechromatographed under neutral conditions but split into both high and low MW forms when rechromatographed in acid. These results indicate that there are at least two circulating forms of NSILA--a low MW form which circulates in serum bound to a carrier protein in an acid-labile high MW complex and a species which circulates only as a stable, discrete high MW protein.

References

Jan 1, 1983·The International Journal of Biochemistry·H J Cornell, A C Herington
Jan 1, 1983·The International Journal of Biochemistry·A C HeringtonA D Kuffer

Citations

Nov 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R M BalaG R Smith
Sep 1, 1975·The Journal of Clinical Endocrinology and Metabolism·K MegyesiP Gorden
Jun 1, 1975·Archives of Biochemistry and Biophysics·J ZapfE R Froesch
Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R C FranklinD P Cameron
Jun 1, 1977·The Journal of Clinical Endocrinology and Metabolism·T HyodoH G Friesen
Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·U KaufmannE R Froesch
Nov 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R L Hintz, F Liu
Nov 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R C FranklinD P Cameron
Dec 1, 1975·The Journal of Clinical Investigation·P L Poffenbarger
Mar 11, 1972·British Medical Journal·W R Russell

Related Concepts

Acromegaly
NSILA-S
Gel Chromatography
Nonsuppressible Insulin-Like Activity
Molecular Sieve Chromatography
Carrier Proteins
Hydrogen-Ion Concentration

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