The occurrence of aneuploidy in human: lessons from the cytogenetic studies of human oocytes

European Journal of Medical Genetics
F PellestorS Hamamah

Abstract

During the last 4 decades, the cytogenetic investigation of human oocytes has never stopped to progress, according to the advents of new technologies. Both karyotyping and molecular cytogenetic studies have been reported to date, providing a large body of data on the incidence and the distribution of chromosomal abnormalities in human female gametes. However, these studies display a great variability in results, which may be essentially attributable to the limitations of these techniques when applied to human oocytes. The most relevant analysis have led to the estimate that 15-20% of human oocytes present chromosome abnormalities, and they have emphasized the implication of both whole chromosome nondisjunction and chromatid separation in the occurrence of aneuploidy in human oocytes. The effect of advanced maternal age on the incidence of aneuploidies in human oocytes has also been clearly evidenced by recent reports based on large sample of oocytes or polar bodies, whereas most of initial studies have failed to confirm any relationship between maternal age and aneuploidy in human oocytes.

References

Dec 1, 1990·Journal of in Vitro Fertilization and Embryo Transfer : IVF·G MichaeliA Amiel
Mar 1, 1989·Human Genetics·M H PietersP P Menheere
Nov 1, 1988·Journal of Reproduction and Fertility·M DjalaliK Sterzik
Jan 15, 1987·The New England Journal of Medicine·H WramsbyP Liedholm
Sep 1, 1985·Journal of in Vitro Fertilization and Embryo Transfer : IVF·H SpielmannR Vogel
Jan 1, 1968·Cytogenetics·C Yuncken
Jan 1, 1996·Journal of Assisted Reproduction and Genetics·A DybanY Verlinsky
Sep 1, 1996·Journal of Assisted Reproduction and Genetics·F PellestorJ P Charlieu
Jul 1, 1997·American Journal of Human Genetics·R Angell
Apr 29, 1998·Human Reproduction·P Nicolaidis, M B Petersen
Sep 8, 1998·Cytogenetics and Cell Genetics·C MárquezS Munné
Jan 1, 1999·Maturitas·U Eichenlaub-Ritter
Apr 3, 2001·Nature Reviews. Genetics·T Hassold, P Hunt
May 25, 2002·Molecular Human Reproduction·Mireia SandalinasSantiago Munné
Aug 31, 2002·Journal of Human Genetics·Nao HondaKoso Ohama
Apr 18, 2003·European Journal of Human Genetics : EJHG·Aïda PujolJoaquima Navarro
Aug 13, 2003·Prenatal Diagnosis·S CupistiJ D A Delhanty
Oct 15, 2003·Fertility and Sterility·Julie M ClydeHelen M Picton
Mar 9, 2004·Cytogenetic and Genome Research·H EckelM Stumm
Mar 25, 2004·Reproductive Biomedicine Online·Mercedes G BermúdezNury M Steuerwald
May 14, 2004·Human Reproduction Update·Lisa G Shaffer, Bassem A Bejjani
Aug 21, 2004·Human Reproduction Update·Anver Kuliev, Yury Verlinsky

❮ Previous
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Citations

Feb 23, 2012·European Journal of Human Genetics : EJHG·Masayo KagamiTsutomu Ogata
Apr 6, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jessica Ezzell HunterStephanie L Sherman
Jun 19, 2012·Nature Reviews. Genetics·So I NagaokaPatricia A Hunt
Feb 14, 2008·Human Reproduction·Laia UrozCristina Templado
Mar 3, 2012·Human Reproduction·L Uroz, C Templado
Aug 25, 2009·Human Reproduction Update·Victor Y FujimotoRichard W Browne
May 31, 2013·Molecular Human Reproduction·C TempladoA Estop
Jun 29, 2010·Reproductive Biology and Endocrinology : RB&E·Alessia NicoliGiovanni B La Sala
Sep 20, 2008·Molecular Cytogenetics·Maj A HulténErik Iwarsson
Nov 27, 2008·Molecular Cytogenetics·Ivan Y IourovYuri B Yurov
Oct 15, 2014·Environmental Health : a Global Access Science Source·Michael S BloomEugen S Gurzau
Feb 28, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Gurpreet Singh Kalra
Nov 29, 2011·Clinics in Laboratory Medicine·Colleen Jackson-Cook
Aug 31, 2012·Science China. Life Sciences·Qian LiQingHua Shi
Nov 27, 2009·Fertility and Sterility·William B SchoolcraftDagan Wells
Oct 10, 2009·Morphologie : Bulletin De L'Association Des Anatomistes·P Vago, UNKNOWN l'équipe de cytogénétique médicale de Clermont-Ferrand
Mar 3, 2009·Fertility and Sterility·Stephanie M NicholsBarry D Bavister
Jun 2, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Veljko VlaisavljevićMojca Cizek-Sajko
Sep 1, 2015·Fertility and Sterility·Michaela NeusserChristian J Thaler
Jan 10, 2008·Cell Proliferation·T A L Brevini, F Gandolfi
Feb 28, 2015·Aging Cell·Evelyne SaadeVasily Ogryzko
Dec 17, 2008·American Journal of Obstetrics and Gynecology·Benjamin D SolomonW Gregory Feero
Feb 2, 2011·Cytogenetic and Genome Research·C TempladoA Estop
Feb 24, 2017·Asian Journal of Andrology·Zaida SarrateFrancesca Vidal
Dec 2, 2015·Obstetrics & Gynecology Science·So Hyun ShimHee Jin Park
Sep 17, 2018·Journal of Assisted Reproduction and Genetics·Deepika Delsa DeanPoonam Tripathi
Jan 4, 2007·The Journal of Pathology·O DjahanbakhchA Zosmer
Jan 29, 2019·Reproduction : the Official Journal of the Society for the Study of Fertility·Jorge Rodriguez-Purata, Francisca Martinez
Jul 11, 2009·Endocrine Reviews·F J BroekmansB C Fauser
Jul 24, 2015·Nature Reviews. Molecular Cell Biology·Stefano Santaguida, Angelika Amon
Dec 25, 2012·Obstetrics and Gynecology·Mandy G Katz-JaffeWilliam B Schoolcraft
Jul 2, 2011·Reproductive Medicine and Biology·Toshifumi TakahashiHirohisa Kurachi
Dec 10, 2019·Science China. Life Sciences·Lu WenZi-Jiang Chen
Jul 1, 2021·Molecular Human Reproduction·Nicoletta TarozziAndrea Borini
Dec 28, 2007·Mutation Research·Ying ShenUrsula Eichenlaub-Ritter
Dec 6, 2008·Genes & Development·Jan-Michael PetersJulia Schmitz

❮ Previous
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