The occurrence of antibiotic resistance genes in the microbiota of yak, beef and dairy cattle characterized by a metagenomic approach.

The Journal of Antibiotics
Weiwei WangJiyu Zhang

Abstract

Drug resistance has been partly driven by the overuse of antimicrobials in agricultural animal feed. Better understanding of antibiotic resistance in bovine gut is needed to assess its potential effects based on metagenomic approach and analysis. In this study, we collected 40 fecal samples to explore drug resistance derived from antibiotic use in the bacterial community by an analysis of the diversities and differences of antibiotic-resistant genes (ARGs) in the gut microbiota from yak, beef, and dairy cattle. Overall, 1688 genes were annotated, including 734 ARG subtypes. The ARGs were related to tetracyclines, quinolones, β-lactam, and aminoglycosides, in accordance with the antibiotics widely used in the clinic for humans or animals. The emergence, prevalence, and differences in resistance genes in the intestines of yaks, beef, and dairy cattle may be caused by the selective pressure of different feeding patterns, where yaks were raised without antibiotics for growth promotion. In addition, the abundance of ARGs in yak was lower than in beef and dairy cattle, whereas the abundance of integron, a kind of mobile genetic elements (MGEs) was higher in yaks than those in beef and dairy cattle. Furthermore, the results of this st...Continue Reading

References

Jul 1, 1993·Molecular Microbiology·C M CollisR M Hall
Aug 28, 2002·International Journal of Medical Microbiology : IJMM·Dean A Rowe-Magnus, Didier Mazel
Mar 10, 2005·Basic & Clinical Pharmacology & Toxicology·Frank M Aarestrup
May 14, 2005·International Journal of Antimicrobial Agents·Xian-Zhi Li
Jul 18, 2006·Nature Reviews. Microbiology·Didier Mazel
Aug 14, 2010·Microbiology·Cecilia JernbergJanet K Jansson
Jun 22, 2011·Genome Research·Daniel H HusonStephan C Schuster
Jun 8, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P MullanyP J Warburton
Jun 29, 2012·Nature·Frank Aarestrup
Sep 1, 2012·Science·Kevin J ForsbergGautam Dantas
Oct 13, 2012·Bioinformatics·Limin FuWeizhong Li
Dec 6, 2012·Nature Communications·Fredrik H KarlssonJens Nielsen
May 8, 2013·Antimicrobial Agents and Chemotherapy·Andrew G McArthurGerard D Wright
Jul 3, 2013·International Journal of Environmental Research and Public Health·Claire VerraesLieve Herman
Oct 8, 2013·Nature Reviews. Immunology·Charlie G Buffie, Eric G Pamer
Feb 11, 2014·Environmental Health Perspectives·Joan A CaseyBrian S Schwartz
May 3, 2014·Environmental Science & Technology·Yuanan Hu, Hefa Cheng
May 23, 2014·Nature·Kevin J ForsbergGautam Dantas
Jun 25, 2014·Current Opinion in Microbiology·Mary D Barton
Jul 6, 2014·Current Opinion in Microbiology·Heather K Allen
Jul 7, 2014·Nature Biotechnology·Junhua LiUNKNOWN MetaHIT Consortium
Nov 18, 2014·Nature Methods·Benjamin BuchfinkDaniel H Huson
Dec 24, 2014·Nature Reviews. Microbiology·José L MartínezFernando Baquero
Jan 31, 2015·Environmental Health Perspectives·Andrew D McEachranPhilip N Smith
Mar 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Thomas P Van BoeckelRamanan Laxminarayan
Apr 29, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark WoolhouseJeremy Farrar
May 23, 2015·Science·Shinichi SunagawaPeer Bork
Jun 19, 2015·Nature·Corie Lok
Mar 1, 2016·Frontiers in Microbiology·Christian J H von WintersdorffPetra F G Wolffs
Oct 9, 2016·Microbiome·Chandan PalD G Joakim Larsson
Oct 22, 2016·Molecular Ecology Resources·Jean-René ArseneauMark Laflamme
Oct 30, 2016·Nucleic Acids Research·Baofeng JiaAndrew G McArthur
May 10, 2017·Nature Chemical Biology·Sonja Petkovic, Winfried Hinrichs

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Methods Mentioned

BETA
Assay

Software Mentioned

Resistance Gene Identifier
CARD
SOAPdenovo2
Scaftigs
MetaGeneMark
Adapter
MEGAN
Soap Aligner

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