PMID: 6986745Feb 1, 1980Paper

The occurrence of hyperaldosteronism in infants with congestive heart failure

The American Journal of Cardiology
B G BaylenS Kaplan

Abstract

Serum aldosterone and plasma renin were measured in 20 normal infants and 15 infants with congestive cardiac failure. Serum aldosterone was significantly increased (151 +/- 38 ng/dl mean +/- standard error of the mean) in patients before treatment when compared with aldosterone in normal infants (29 +/- 7 ng/dl). Increasing serum aldosterone was related to increasing plasma renin. The response to furosemide appeared to be inversely related to serum aldosterone concentrations. In four infants, administration of an aldosterone antagonist (spironolactone) resulted in improved diuresis and decreased serum aldosterone. Hyperaldosteronism is an important factor contributing to fluid and sodium retention in infants with heart failure.

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Citations

May 1, 1993·British Journal of Clinical Pharmacology·J P DutertreJ Laugier
Feb 24, 2006·Paediatric Drugs·Kazuo Momma
Jan 24, 1986·The American Journal of Cardiology·M K WitteJ L Blumer
Mar 1, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Simonetta CostaFrancesca Gallini
Apr 7, 2005·The Annals of Pharmacotherapy·Marcia L Buck
Jan 18, 2012·Current Opinion in Cardiology·Kathleen E Simpson, Charles E Canter
Jan 23, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jean-Pierre Guignard, Silvia Iacobelli

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