The occurrence of hypothyroidism following radioactive iodine treatment of toxic nodular goiter is related to the TSH level

Irish Journal of Medical Science
H I AdamaliT J McKenna


Strategies to increase frequency of euthyroidism following radioactive (RAI) treatment of hyperthyroidism are required. To examine the role of TSH in development of hypothyroidism post RAI treatment in patients with Graves' disease (N = 98) or toxic nodular goiter, TNG (N = 88). This retrospective study examined thyroid status over a mean of 3.7 years post-RAI. Although RAI dose was significantly higher in TNG group, hypothyroidism occurred more frequently in Graves' disease (71.4 and 22.7%) P < 0.001. The TSH levels at the time of RAI treatment were lower in TNG patients who remained euthyroid, (0.4+/-0.1 vs. 1.2+/-0.5 mU/l, P < 0.0022). A higher frequency of euthyroidism occurs in patients with TNG than with Graves' disease following RAI, particularly when suppressed TSH levels were suppressed at time of RAI-treatment.


Jan 1, 1978·Seminars in Nuclear Medicine·W H Beierwaltes
May 1, 1975·Archives of Internal Medicine·A M Safa, P G Skillern
Sep 26, 1992·BMJ : British Medical Journal·J Franklyn, M Sheppard
Dec 9, 1967·Lancet·P A BastenieP Neve
Jan 17, 1974·The New England Journal of Medicine·J L CevallosE M Chapman
Nov 22, 1997·European Journal of Endocrinology·U Pedersen-Bjergaard, C Kirkegaard
Feb 19, 1998·The Journal of Clinical Endocrinology and Metabolism·R E ImseisN R Vanmiddlesworth
Sep 1, 1999·Clinical Endocrinology·R Le MoliW M Wiersinga
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·A AllahabadiaJ A Franklyn
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Erik K Alexander, P Reed Larsen
Mar 28, 2002·Thyroid : Official Journal of the American Thyroid Association·Milena BragaDavid S Cooper
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·William D LeslieElizabeth A Cowden
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Anne R Cappola, Paul W Ladenson
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·S J BonnemaL Hegedüs
Jul 7, 2005·JAMA : the Journal of the American Medical Association·Jayne A FranklynPatrick Maisonneuve

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