PMID: 8951208Nov 1, 1996Paper

The occurrence of multiple sclerosis in the Hutterites of North America

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
W J HaderD W Dietrich

Abstract

To report the occurrence, clinical characteristics and genealogical analysis of multiple sclerosis in the Hutterites of North-Western United States and Western Canada. The incidence of multiple sclerosis is reported to be lower or rare in certain ethnic groups and genetic isolates and was previously observed to be absent in the Hutterite population. After long-term surveillance, six patients were identified and clinical examinations and laboratory investigations including VER and MRI were completed. The six cases included two brothers, two first cousins, male and female, another male and female, all representing two of the three endogamous groups of Hutterites, are linked to two common ancestors through lines of descent dating to 1723. The individual pedigrees were analyzed from extensive genealogical records covering eight generations. The incidence of multiple sclerosis in Hutterites is low in a high risk area of North America. A specific mode of inheritance pattern has not been established and a common founder effect may play a role in the development of multiple sclerosis. The genetic contribution of the Hutterites seems greater than previously recognized.

References

Oct 26, 1989·Nature·D E McFarlin, P J Lachmann
Jun 30, 1988·The New England Journal of Medicine·R CarmelD S Rosenblatt
Dec 25, 1986·The New England Journal of Medicine·G C EbersT Grey
Nov 1, 1985·American Journal of Medical Genetics·R B LowryS W Gilroy
Nov 1, 1985·American Journal of Medical Genetics·J A Hostetler
Nov 1, 1985·American Journal of Medical Genetics·M H Shokeir, B Rozdilsky
Nov 1, 1985·American Journal of Medical Genetics·P D Pallister, J M Opitz
May 1, 1970·American Journal of Physical Anthropology·A O Martin
Nov 1, 1966·Archives of Neurology·R P Mackay, N C Myrianthopoulos
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jan 1, 1951·Brain : a Journal of Neurology·R T C PRATTD McALPINE
Aug 1, 1967·Neurology·H E Cross, V A McKusick

❮ Previous
Next ❯

Citations

Mar 29, 2014·Multiple Sclerosis International·Walter J Hader, Irene M Yee
Dec 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·David Alexandre DymentGeorge C Ebers
Mar 1, 2014·International Journal of Molecular Sciences·Klaus Lauer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Neurology
Ilse A HoppenbrouwersRogier Q Hintzen
South Dakota Medicine : the Journal of the South Dakota State Medical Association
Jason D FlanaganLaura Davis Keppen
Journal of the American Medical Informatics Association : JAMIA
Patricia KosseimProton Rahman
Community Dentistry and Oral Epidemiology
J Hoover, J Tynan
South Dakota Medicine : the Journal of the South Dakota State Medical Association
Stacy Peters, Olayinka Shiyanbola
© 2021 Meta ULC. All rights reserved