The occurrence of non-melanoma malignant skin lesions and non-cutaneous squamous-cell carcinoma among metastatic melanoma patients: an observational cohort study in Denmark

BMC Cancer
Haojie LiJeanenne J Nelson


Inhibitors of mutant BRAF are emerging as standard of care in patients with metastatic melanoma who carry relevant oncogenic mutations. However, BRAF inhibitors are found to induce cutaneous squamous cell carcinoma (cuSCC). Population-based background rates of cuSCC and non-cutaneous squamous cell carcinoma (non-cuSCC) in the metastatic melanoma population may contextualize safety signals from randomized clinical trials or the clinics. However, these background rates are lacking. We conducted a historical cohort study to evaluate the background rates of new-onset non-melanoma skin lesions and non-cuSCC among 2,814 metastatic malignant melanoma patients diagnosed in 1997-2010, identified through the Danish Cancer Registry and the National Pathology Registry. Patients were excluded if they had a history of cancer before the metastatic melanoma diagnosis, other than skin cancers. We determined the incidence of non-melanoma malignant skin lesions and non-cuSCC that occurred post metastatic melanoma diagnosis, censoring patients at death, emigration, or December 31, 2011 (end of study period), whichever came first. The median age at metastatic melanoma diagnosis was 64 years. Over 40% of patients died within one year of metastatic d...Continue Reading


Sep 1, 1986·Annals of Internal Medicine·R Simon
Feb 1, 1984·Journal of the American Academy of Dermatology·M A Goldenhersh, T G Olsen
Aug 1, 1993·The American Journal of Dermatopathology·E HodakA B Ackerman
Dec 11, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·B CribierE Grosshans
Dec 22, 1999·Journal of the American Academy of Dermatology·R G Glogau
May 27, 2006·The Journal of Investigative Dermatology·Ole Petter F ClausenPaula M Deangelis
Jul 17, 2008·Journal of Cutaneous Medicine and Surgery·Renata Ferreira MagalhãesAparecida Machado de Moraes
Dec 20, 2008·Clinics in Dermatology·Claus Garbe, Ulrike Leiter
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Fatima Birch-JohansenSusanne K Kjær
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanBRIM-3 Study Group
Aug 4, 2011·Scandinavian Journal of Public Health·Marianne Lundkjær Gjerstorff
Jun 6, 2012·The New England Journal of Medicine·Keith T FlahertyMETRIC Study Group
May 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J D WolchokC Lebbé
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtH T Sørensen


Related Concepts

BRAF protein, human
Cutaneous Melanoma
Pigmented Basal Cell Carcinoma
Squamous Cell Carcinoma
Malignant Neoplasm of Skin
Incidence Studies
Proto-Oncogene Proteins B-raf
Actinic Keratosis
Bowen's Disease

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.