The occurrence of polycyclic aromatic hydrocarbons and their derivatives and the proinflammatory potential of fractionated extracts of diesel exhaust and wood smoke particles

Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Annike Irene TotlandsdalAlena Kubátová

Abstract

Exposure to combustion emissions, including diesel engine exhaust and wood smoke particles (DEPs and WSPs), has been associated with inflammatory responses. To investigate the possible role of polycyclic aromatic hydrocarbons (PAHs) and PAH-derivatives, the DEPs and WSPs methanol extracts were fractionated by solid phase extraction (SPE), and the fractions were analyzed for more than ∼120 compounds. The pro-inflammatory effects of the fractionated extracts were characterized by exposure of bronchial epithelial lung cells (BEAS-2B). Both native DEPs and WSPs caused a concentration-dependent increase in IL-6 and IL-8 release and cytotoxicity. This is consistent with the finding of a rather similar total content of PAHs and PAH-derivatives. Yet, the samples differed in specific components, suggesting that different species contribute to the toxicological response in these two types of particles. The majority of the IL-6 release and cytotoxicity was induced upon exposure to the most polar (methanol) SPE fraction of extracts from both samples. In these fractions hydroxy-PAHs, carboxy-PAHs were observed along with nitro-amino-PAHs in DEP. However, the biological effects induced by the polar fractions could not be attributed only to t...Continue Reading

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Citations

Jan 2, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A O LawalJ L Marnewick
Jun 7, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Abdullah MayatiJohan Ovrevik
May 20, 2016·Environmental Pollution·Eleonora LonghinMarina Camatini
Dec 22, 2016·Basic & Clinical Pharmacology & Toxicology·Johan ØvrevikJørn A Holme
Feb 17, 2017·American Journal of Respiratory Cell and Molecular Biology·Carolyn BlackLisa A Miller
Jan 9, 2018·Annual Review of Pharmacology and Toxicology·Arthur K Cho
Aug 14, 2020·Particle and Fibre Toxicology·Jayme P CoyleLiying W Rojanasakul
Dec 12, 2017·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Isabel C JaramilloKerry E Kelly
Oct 13, 2018·The Science of the Total Environment·Sara MarchettiParide Mantecca

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