The occurrence of seizures after ischemic stroke does not influence long-term mortality; a 26-year follow-up study

Journal of Neurology
J H van TuijlR P W Rouhl

Abstract

Epileptic seizures are a common complication after stroke. The relation between occurrence of seizures after stroke and long-term mortality remains elusive. We aimed to assess whether seizures in an early or late phase after ischemic stroke are an independent determinant of long-term mortality. We prospectively included and followed 444 ischemic stroke patients with a first-ever supratentorial brain infarct for at least 2 years after their stroke regarding the occurrence of seizures. The final follow-up for mortality is from April 2015 (follow-up duration 24.5-27.8 years, mean 26.0 years, SD 0.9 years). We compared patients with early-onset seizures with all seizure-free patients, whereas the patients with late-onset seizures were compared with the 1-week survivors without any seizures. We used Cox-regression analyses to correct for possible confounding factors. Kaplan-Meier analysis showed significantly higher mortality for the patients with early-onset seizures (p = 0.002) but after correction for known risk factors for (long term) mortality early-onset seizures had no independent influence on long-term mortality (HR 1.09; 95% CI 0.64-1.85). In patients with late-onset seizures, no significant influence from late-onset seizur...Continue Reading

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Citations

Feb 24, 2021·Drugs & Aging·Marian GalovicMatthias J Koepp
May 3, 2021·Seizure : the Journal of the British Epilepsy Association·M AlemanyP Cardona
May 4, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Olivier Masheka-CishesaBarbara Casolla
Jun 16, 2021·Stroke; a Journal of Cerebral Circulation·Felipe J S JonesLidia M V R Moura

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