The ocular melanoma story. LIII Edward Jackson Memorial Lecture: Part II

American Journal of Ophthalmology
D M Albert

Abstract

To trace the evolution and status of our knowledge of choroidal melanoma with regard to the nature, cause, and treatment of this tumor. Historical materials beginning with Georg Bartisch's contributions in 1583 through to the Collaborative Ocular Melanoma Study and recent basic research are reviewed. Many individuals have made important contributions to our knowledge about this tumor. Basic information, however, regarding the natural history of the tumor, the most effective treatment, and its cause is lacking. The Collaborative Ocular Melanoma Study will provide important information regarding the choice of treatment between enucleation and radiotherapy as well as natural history information, quality of life, and definitive pathology findings. Definitive treatment of choroidal melanoma will depend on knowledge of the genetic defects that cause the tumor. Within the next 25 years, it is predicted that genetic defects will be determined and tumor samples will be obtained using small-needle aspiration and DNA probes located on microchips. In addition, treatment will then be based on drugs designed to inhibit molecules related to the genetic defect in the tumor.

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Citations

Sep 10, 2005·International Journal of Cancer. Journal International Du Cancer·Shixuan WangJerry Y Niederkorn
Sep 1, 2004·Biochemical and Biophysical Research Communications·Lalita Subramanian, Arthur S Polans
May 24, 2001·Hematology/oncology Clinics of North America·J E Munzenrider
Dec 2, 2008·Journal of Cellular and Molecular Medicine·Lyndsay DaviesLuminita Paraoan
Mar 10, 2007·World Journal of Surgical Oncology·Manoj PandeyKrishnankutty Ramachandran
Oct 23, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianjun BiShengfang Ge
Jun 1, 2001·American Journal of Ophthalmology·R J GrosternUNKNOWN Collaborative Ocular Melanoma Study Group
Sep 2, 2016·British Journal of Cancer·Raheela AwaisLuminita Paraoan
Apr 14, 2016·Radiology and Oncology·Boris JancarDusica Pahor
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·M C Kincaid
Feb 16, 2016·Radiology and Oncology·Boris JancarDusica Pahor
Jan 12, 2008·British Journal of Hospital Medicine·Ahmed Sallam, John Hungerford

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