The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study

Scientific Reports
L AgnifiliRodolfo Mastropasqua

Abstract

We investigated the ocular surface (OS) system modifications after completely successful glaucoma surgery in thirty-eight patients undergoing trabeculectomy (surgical group), using laser scanning confocal microscopy (LSCM) and impression cytology (IC). Twenty-six medically controlled glaucomatous patients served as controls (medical group). LSCM, IC, and the ocular surface disease index (OSDI) and National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) questionnaires, were performed at baseline and after six months. The main outcomes were: goblet cell density (GCD), limbal dendritic cell density (LDCD), subbasal corneal nerve inhomogeneity (SCNI), Meibomian gland density and inhomogeneity (MGD, MGI), and HLA-DR positivity. There were no significant baseline differences between groups. At the sixth month, the surgical group showed a GCD increase (p < 0.001), and a LDCD, SCNI, MGI, HLA-DR (p < 0.001), OSDI and NEI VFQ-25 scores decrease (p < 0.05). The medical group did not show significant OS modifications, showing LSCM and IC parameters significantly worse compared to the surgical group (p < 0.001). The OSDI score correlated with GCD, MGI, SCNI, LDCD, and HLA-DR (p < 0.001; p < 0.05; p < 0.01). The present study fo...Continue Reading

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Citations

Dec 8, 2020·Expert Opinion on Drug Delivery·Michele FigusChiara Posarelli
Dec 17, 2020·Asia-Pacific Journal of Ophthalmology·Lisa M NijmMinas Theodore Coroneo
Jan 26, 2021·Current Opinion in Ophthalmology·Laura Voicu, Sarwat Salim
Feb 9, 2021·Current Opinion in Ophthalmology·Laura Voicu, Sarwat Salim
May 19, 2021·Translational Vision Science & Technology·Leonardo MastropasquaRodolfo Mastropasqua

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

Cell Count
SPSS
HFA Guided Progression Analysis
SPSS Advanced Statistical TM

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