The odd-carbon medium-chain fatty triglyceride triheptanoin does not reduce hepatic steatosis

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Tine M ComhairS Eleonore Koehler

Abstract

Non-alcoholic fatty-liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Previously, we showed that a high-protein diet minimized diet-induced development of fatty liver and even reversed pre-existing steatosis. A high-protein diet leads to amino-acid catabolism, which in turn causes anaplerosis of the tricarboxylic-acid (TCA) cycle. Therefore, we hypothesized that anaplerosis of the TCA cycle could be responsible for the high-protein diet-induced improvement of NAFLD by channeling amino acids into the TCA cycle. Next we considered that an efficient anaplerotic agent, the odd-carbon medium-chain triglyceride triheptanoin (TH), might have similar beneficial effects. C57BL/6J mice were fed low-fat (8en%) or high-fat (42en%) oleate-containing diets with or without 15en% TH for 3 weeks. TH treatment enhanced the hepatic capacity for fatty-acid oxidation by a selective increase in hepatic Ppara, Acox, and Cd36 expression, and a decline in plasma acetyl-carnitines. It also induced pyruvate cycling through an increased hepatic PCK1 protein concentration and it increased thermogenesis reflected by an increased Ucp2 mRNA content. TH, however, did not reduce hepatic lipid content. The comparison of the present ef...Continue Reading

Citations

Nov 30, 2019·The British Journal of Nutrition·Isaac AmpongHelen R Griffiths
Nov 30, 2019·Journal of Inherited Metabolic Disease·Zeinab Wehbe, Sara Tucci
Jul 8, 2017·Neural Plasticity·Ekaterina VeniaminovaTatyana Strekalova

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