PMID: 7334529Jan 1, 1981Paper

The old REH theory remains unsatisfactory and the new REH theory is problematical - a reply to Holmquist and Jukes

Journal of Molecular Evolution
W M Fitch

Abstract

In response to criticism of REH theory (Fitch 1980), Holmquist and Jukes (1981) have mostly avoided the criticism or misunderstood it. Since they themselves state in their response that "Amino acid sequence data alone cannot be used to estimate total nucleotide substitutions," they agree with the criticism. Most of their paper treats the newer theory (here designated as the REHN theory) which attempts to use the nucleotide sequences encoding proteins to better estimate total nucleotide substitutions (Holmquist and Pearl 1980). Since I made no criticism of REHN theory, their comments are frequently beside the point of my original criticism of REH theory. Nevertheless, it is shown here that REHN theory is also unsatisfactory in that: One, the varions are now more clearly defined but in such a way as to preclude the same codon from suffering a nucleotide substitution in more than one evolutionary interval. Two, the set of codons that accepts silent substitutions is identical to the set that accepts amino acid changing nucleotide substitutions. Three, the uncertainty in the REH estimate is considerable in that alternative excellent fits to the same observational data may give alternative REH values that differ significantly even be...Continue Reading

References

Oct 6, 1978·Journal of Molecular Evolution·R Holmquist
Sep 1, 1976·British Medical Bulletin·N J Proudfoot, G G Brownlee
Nov 29, 1974·Annals of the New York Academy of Sciences·M D GarrickL M Garrick
Jan 1, 1973·Annual Review of Genetics·W M Fitch
Mar 1, 1973·Journal of Theoretical Biology·G W MooreM Goodman
Jun 14, 1968·Annals of the New York Academy of Sciences·E Margoliash, W M Fitch
Jan 1, 1981·Journal of Molecular Evolution·R Holmquist, T H Jukes
Jan 1, 1963·Advances in Biological and Medical Physics·T H JUKES

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Citations

Jan 1, 1987·Journal of Molecular Evolution·D F Feng, R F Doolittle
Jan 1, 1983·Bio Systems·A B McQuade
Jan 29, 1986·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W M Fitch

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