PMID: 9438796Jan 23, 1998Paper

The olfactory thalamocortical system and odor reversal learning examined using an asymmetrical lesion paradigm in rats

Behavioral Neuroscience
S A McBride, B M Slotnick

Abstract

The olfactory thalamocortical system was disrupted bilaterally in rats using (a) unilateral mediodorsal thalamic (MD) lesions plus contralateral bulbectomy and transection of the anterior commissure (AC), (b) unilateral MD lesions plus contralateral lesions of the frontal cortex, or (c) bilateral MD lesions. Rats were trained on an odor discrimination task and on the reversal of that task. Experimental groups performed as well as controls on the initial discrimination task but made more errors on the reversal problem. Rats with asymmetrical disruption of the olfactory thalamocortical system performed as poorly as those with bilateral MD lesions. These outcomes indicate that odor reversal learning deficits in rats with bilateral MD lesions stem from interruption of the olfactory thalamic-neocortical system and also provide evidence that the AC mediates significant interhemispheric transfer of olfactory information.

Citations

May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jane PlaillyJay A Gottfried
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph L Price, Wayne C Drevets
Jul 7, 2010·Experimental Brain Research·Lee Sela, Noam Sobel
Jul 23, 1999·Annals of the New York Academy of Sciences·J L Price

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