The Omics Revolution Continues: The Maturation of High-Throughput Biological Data Sources

Yearbook of Medical Informatics
Ewy MathéJames L Chen

Abstract

The aim is to provide a comprehensive review of state-of-the art omics approaches, including proteomics, metabolomics, cell-free DNA, and patient cohort matching algorithms in precision oncology. In the past several years, the cancer informatics revolution has been the beneficiary of a data explosion. Different complementary omics technologies have begun coming into their own to provide a more nuanced view of the patient-tumor interaction beyond that of DNA alterations. A combined approach is beneficial to the patient as nearly all new cancer therapeutics are designed with an omics biomarker in mind. Proteomics and metabolomics provide us with a means of assaying in real-time the response of the tumor to treatment. Circulating cell-free DNA may allow us to better understand tumor heterogeneity and interactions with the host genome. Integration of increasingly available omics data increases our ability to segment patients into smaller and smaller cohorts, thereby prompting a shift in our thinking about how to use these omics data. With large repositories of patient omics-outcomes data being generated, patient cohort matching algorithms have become a dominant player. The continued promise of precision oncology is to select patien...Continue Reading

Citations

Aug 15, 2020·Neuro-oncology Advances·Lennard J M DekkerTheo M Luider
Jun 15, 2019·Expert Review of Proteomics·N Corbacho-AlonsoM G Barderas
Mar 16, 2021·Acta Biomaterialia·Mackenzie L Grubb, Steven R Caliari

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Methods Mentioned

BETA
nuclear magnetic resonance
xenografts
proteome exchange
NMR
biopsy
PCR
biopsies
exome sequencing

Clinical Trials Mentioned

NCT03085888

Software Mentioned

ORIEN
Metabox
Metabolomics Workbench
CancerLinQ
Syapse
MetaboAnalyst
PHenotypic Interpretation of Variants Exomes ( PHIVE
Sync
PeptideAtlas
GeneYenta

Related Concepts

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Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

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