The oncologic impact of hormone replacement therapy in premenopausal breast cancer survivors: A systematic review

The Breast : Official Journal of the European Society of Mastology
Yimeng WangAdena S Scheer

Abstract

This is the first systematic review to investigate the risk of recurrence in breast cancer survivors <50 years old who have used hormone replacement therapy (HRT). The risk of HRT in premenopausal breast cancer survivors is unclear. Due to the higher incidence of estrogen receptor negative tumours in women <50, the potential for HRT to promote breast cancer recurrence may differ from older age groups. We performed a search of Medline, EMBASE and CINAHL through June 2016. For the observational studies relative risk (RR) and 95% confidence interval (CI) were calculated for the recurrence rate among HRT users and nonusers. A random effects model was used to estimate the combined RR using the Mantel-Haenszel method. Four papers satisfied our inclusion criteria. 3477 subjects were analyzed. On pooled meta-analysis of breast cancer recurrence in the observational studies, no significant association was found between HRT and risk of recurrence (RR 1.04 [95% CI 0.45, 2.41]). The randomized controlled trial (RCT) included found an increased risk of recurrence with HRT among women <50 (HR 1.56 [95% CI 1.1-2.2]). However, among women of all ages with an estrogen receptor negative tumour there was no significant difference in recurrence wh...Continue Reading

Citations

Aug 14, 2018·Current Opinion in Supportive and Palliative Care·Ryan N MontalvoJames A Carson
Nov 19, 2019·Menopause : the Journal of the North American Menopause Society·Benjamin S HarrisThomas M Price
Jan 29, 2021·Molecular and Cellular Endocrinology·Stacy K Ugras, Rakhshanda Layeequr Rahman

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