The ongoing evolution of basal insulin therapy over 100 years and its promise for the future.

Diabetes, Obesity & Metabolism
Ravi Retnakaran, Bernard Zinman

Abstract

The evolution of basal insulin therapy over the past 100 years since the discovery of insulin is a testimony to the biomedical bench-to-bedside process, wherein incremental advances in the basic sciences are progressively translated over time into a series of enhancements in clinical care, each building upon the success of its predecessors. The emergence of recombinant DNA technology and the resultant biosynthesis of human insulin in the 1980s provided the critical capacity to bioengineer designer insulin analogues with pharmacokinetic and pharmacodynamic properties that can better mimic, although not fully replicate, the effects of endogenous insulin secretion. Through these efforts, basal insulin therapy has progressed over this time from first-generation analogues (glargine U-100, detemir) to second-generation analogues (glargine U-300, degludec) to ultra-long-acting formulations that are suitable for administration once weekly (icodec). Each iteration in this progression has represented a step closer towards the goal of replicating the continuous secretion of insulin that normally comprises the basal output of the pancreatic beta-cells between meals, during episodes of fasting and overnight. However, it may be that we may h...Continue Reading

References

Nov 1, 1979·Diabetologia·T LauritzenC Binder
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·B ZinmanE B Marliss
Aug 10, 1989·The New England Journal of Medicine·B Zinman
Jan 20, 1984·JAMA : the Journal of the American Medical Association·H C HagedornI Wodstrup
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Apr 29, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·L HeinemannT Heise
Sep 12, 2000·Lancet·G B Bolli, D R Owens
Sep 12, 2001·Lancet·D R OwensG B Bolli
Aug 6, 1960·Nature·D S NICOL, L F SMITH
Sep 14, 2004·Pharmaceutical Research·Svend HavelundPeter Kurtzhals
Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Michael F Dunn
Mar 10, 2009·Diabetes, Obesity & Metabolism·M MonamiE Mannucci
Jan 6, 2011·The Annals of Pharmacotherapy·Erika PollexDenice S Feig
Jun 13, 2012·The New England Journal of Medicine·Hertzel C GersteinSalim Yusuf
Dec 18, 2012·Diabetes, Obesity & Metabolism·S C L GoughM Davies
Dec 18, 2014·American Journal of Physiology. Endocrinology and Metabolism·Tiffany D FarmerMasakazu Shiota
Jun 14, 2015·American Journal of Obstetrics and Gynecology·Kimberly M HerreraLois E Brustman
Jun 13, 2017·The New England Journal of Medicine·Steven P MarsoUNKNOWN DEVOTE Study Group
Jul 4, 2017·JAMA : the Journal of the American Medical Association·Wendy LaneUNKNOWN SWITCH 1

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