The ongoing French metastatic breast cancer (MBC) cohort: the example-based methodology of the Epidemiological Strategy and Medical Economics (ESME)

BMJ Open
David PérolGaëtane Simon

Abstract

The currently ongoing Epidemiological Strategy and Medical Economics (ESME) research programme aims at centralising real-life data on oncology care for epidemiological research purposes. We draw on results from the metastatic breast cancer (MBC) cohort to illustrate the methodology used for data collection in the ESME research programme. All consecutive ≥18 years patients with MBC treatment initiated between 2008 and 2014 in one of the 18 French Comprehensive Cancer Centres were selected. Diagnostic, therapeutic and follow-up data (demographics, primary tumour, metastatic disease, treatment patterns and vital status) were collected through the course of the disease. Data collection is updated annually. With a recruitment target of 30 000 patients with MBC by 2019, we currently screened a total of 45 329 patients, and >16 700 patients with a metastatic disease treatment initiated after 2008 have been selected. 20.7% of patients had an hormone receptor (HR)-negative MBC, 73.7% had a HER2-negative MBC and 13.9% were classified as triple-negative BC (ie, HER2 and HR status both negative). Median follow-up duration from MBC diagnosis was 48.55 months for the whole cohort. These real-world data will help standardise the management of...Continue Reading

Citations

Aug 22, 2020·Yearbook of Medical Informatics·Xosé M Fernández
May 16, 2019·International Journal of Cancer. Journal International Du Cancer·William JacotAudrey Mailliez
Aug 3, 2020·Fundamental & Clinical Pharmacology·Emilie CasarottoMathieu Molimard
Dec 12, 2020·The Breast : Official Journal of the European Society of Mastology·Khalil SalehElise Deluche
Nov 12, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Paul CottuXavier Pivot
Feb 10, 2021·The Breast : Official Journal of the European Society of Mastology·Luc CabelFlorence Lerebours
May 8, 2020·The Breast : Official Journal of the European Society of Mastology·Sophie FrankPaul Cottu

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT03275311

Software Mentioned

eCRF
SAS
Oracle

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.