The ongoing saga of the mechanism(s) of MHC class I-restricted cross-presentation

Current Opinion in Immunology
Jeff E GrotzkePeter Cresswell

Abstract

Cross-presentation is an MHC-I antigen processing pathway that results in the presentation of peptides from exogenous viral, bacterial, parasitic, and tumor antigens and ultimately leads to priming of naïve CD8+ T cells. This process involves several cellular compartments and multiple components. Successful generation of MHC-I-peptide complexes requires that these components act together in a coordinated fashion. We discuss recent findings on the source of MHC-I, the role of the TAP transporter, the importance of intracellular trafficking events, mechanisms of antigen access the cytosol, and how innate immune signals can affect presentation, with an emphasis on how these pathways compare to conventional antigen presentation and how they correlate with existing data.

Citations

Mar 1, 2018·Annual Review of Immunology·J Magarian Blander
Jul 7, 2019·Cancer Immunology, Immunotherapy : CII·Zhengyuan LiMinghui Zhang
Jul 5, 2019·The EMBO Journal·Debrup SenguptaPeter Cresswell
May 16, 2018·Frontiers in Cell and Developmental Biology·Rupert Abele, Robert Tampé
Apr 5, 2019·JCI Insight·Abigail L SedlacekRobert J Binder
Aug 8, 2018·Nature Communications·Qiao LuPeter Cresswell
May 27, 2020·Molecular & Cellular Proteomics : MCP·Nataly Mancette RijenskyArie Admon
Aug 21, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Timo BursterAnuar Zhanapiya
Oct 18, 2020·International Journal of Molecular Sciences·Dirk M Zajonc
Dec 15, 2020·Current Protocols in Immunology·Barzan A SadiqJ Magarian Blander
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Nataly Mancette RijenskyArie Admon
Mar 9, 2021·Frontiers in Immunology·Maksim V BaranovGeert van den Bogaart
Jul 3, 2021·Pharmaceutics·Maarten K Nijen TwilhaarJoke M M den Haan
Jun 28, 2021·Cells & Development·Robert R Kay

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