PMID: 1352934Apr 1, 1992

The onset of dopaminergic innervation during ontogeny decreases melanotrope proliferation in the intermediate lobe of the rat pituitary

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
K A Gary, B M Chronwall

Abstract

The onset of dopaminergic innervation and its effects on melanotrope proliferation were investigated in the rat pituitary intermediate lobe. Dopamine, and its synthetic rate-limiting enzyme tyrosine hydroxylase, were first detected immunohistochemically on late post-natal day 3 or early postnatal day 4. Axon density was highest at the neural lobe/intermediate lobe border, and decreased toward the pituitary cleft. By postnatal day 10, the adult pattern of tyrosine hydroxylase immunoreactivity was established and remained through post-natal day 14. Neurointermediate lobe dopamine levels, measured by HPLC, correlated well with the increased axon density observed in the immunohistochemical studies. Dopamine could not be measured by our assay (100 fg limit) until post-natal day 3 (439.32 fg/NIL). Dopamine concentration increased to 2.09 +/- 0.425 ng at PN 4, 86.31 +/- 20.42 ng at PN 7, 168.72 +/- 18.37 ng at PN 10. Melanotrope proliferation was determined by [3H]thymidine incorporation before and after innervation. Concomitant with the onset of innervation, the proliferation index dropped from 13.4 +/- 0.01% to 6.5 +/- 0.002% at PN 4, and continued to decrease until a level of 3 +/- 0.003% was established by PN 10. To confirm the in...Continue Reading

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Citations

Oct 1, 1994·Molecular and Cellular Endocrinology·F RenéJ M Félix
Oct 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K A GaryB M Chronwall
Oct 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A SandsB M Chronwall
Apr 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B M ChronwallK A Gary
Apr 5, 2005·Brain Research. Developmental Brain Research·Irina G MakarenkoAndre Calas
Jun 2, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Maya Gadhvi PurisaiB M Chronwall
Jun 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Sands, B M Chronwall
Apr 1, 1994·Journal of Neuroendocrinology·E MaF Ellendorff
May 31, 1993·Annals of the New York Academy of Sciences·F RenéM E Stoeckel
May 31, 1993·Annals of the New York Academy of Sciences·B M ChronwallK A Gary
Jun 16, 2011·Biomedical Research·Toshihiko IwanagaHiromi Takahashi-Iwanaga
Apr 7, 2007·European Journal of Endocrinology·Rosario PivonelloLeo J Hofland
Sep 14, 2000·Brain & Development·K Kobayashi, H Sano
Jan 5, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·K Kobayashi
Dec 30, 2014·Frontiers in Neuroanatomy·Irina G Makarenko
Mar 17, 2004·Oncogene·Sandra W LeungLili Yamasaki
Dec 12, 2001·Endocrine Reviews·N Ben-Jonathan, R Hnasko
Aug 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D M BeattyB M Chronwall
Oct 1, 2010·American Sociological Review·Jacob S Rugh, Douglas S Massey
Jul 24, 2003·American Journal of Physiology. Endocrinology and Metabolism·Rafael Vazquez-MartinezMaria M Malagon

Related Concepts

Metazoa
Cell Division Phases
High Pressure Liquid Chromatography Procedure
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Thymidine
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