The onset of lipid peroxidation in rheumatoid arthritis: consequences and monitoring

Free Radical Research
Wojciech ŁuczajElżbieta Skrzydlewska

Abstract

Several epidemiological studies propose the association of rheumatoid arthritis (RA) with oxidative stress. The aim of this study was to estimate the possible onset of systemic lipid peroxidation in RA patients and its relevance for pathophysiology and monitoring of RA. Seventy-three patients with RA and 73 healthy subjects were included in the study. Lipid peroxidation was estimated by the measurement of 4-hydroxynonenal (4-HNE), 4-hydroxyhexenal, malondialdehyde, acrolein, crotonaldehyde, 4-oxononenal, and isoprostanes (8-isoPGF(2α)) levels. Cytosolic phospholipase A(2) (cPLA(2)), platelet-activating factor acetylhydrolase (PAF-AH) and glutathione peroxidase (GSH-Px) activities and vitamin E levels were also determined. In parallel, the plasma levels of phospholipid arachidonic acid (AA), linoleic acid (LA), and 4-HNE-protein adducts were monitored. Plasma of RA patients had increased vitamin E levels, but decreased GSH-Px activity and phospholipid AA and LA levels when compared to levels of the healthy subjects. The levels of aldehydes were significantly increased in the plasma of the RA patients and even more in urine. Significant increases in HNE-modified protein adducts was observed for the first time in plasma of RA pati...Continue Reading

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Citations

Apr 17, 2017·Redox Biology·Agnieszka GęgotekElżbieta Skrzydlewska
Jun 19, 2019·Current Pharmaceutical Design·Allison B ReissJoshua De Leon
Apr 26, 2018·Modern Rheumatology·Paul R J AmesJaffar Nourooz-Zadeh
Feb 6, 2017·Biomarkers in Medicine·James Sm CuffeAnthony V Perkins
Jul 13, 2017·Oxidative Medicine and Cellular Longevity·Ilaria MarroccoIlaria Peluso
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Anna PreschaHalina Grajeta
May 1, 2020·International Journal of Molecular Sciences·Michele Dei CasFrancesco Secundo
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Oct 24, 2018·Analytical Chemistry·Songtao XiangShunbo Li

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