The onset of rocuronium, but not of vecuronium or mivacurium, is modified by tourniquet inflation

Anesthesia and Analgesia
G Audibert, F Donati

Abstract

A previous investigation showed that inflation of a tourniquet did not interrupt onset of vecuronium neuromuscular block. To test the hypothesis that this effect depended on potency, twitch tension was measured in an arm with a tourniquet inflated during onset and compared with a control arm in 30 patients under fentanyl-thiopental-nitrous oxide-isoflurane anesthesia. Patients were randomly allocated to receive either vecuronium 0.1 mg/kg (n = 10), rocuronium 0.6 mg/kg (n = 10), or mivacurium 0.2 mg/kg (n = 10). The electromyographic response of the first dorsal interosseus to single twitch stimulation of the ulnar nerve every 10 s was recorded in both arms. When neuromuscular block was 20% (i.e., twitch tension was 80% of control), the tourniquet was inflated to a pressure of 300 mm Hg. It was deflated 5 min later. In the vecuronium and mivacurium groups, the tourniquet did not influence onset of block. In the rocuronium group, maximum neuromuscular block was (mean +/- SD) 79% +/- 10% in the tourniquet arm, compared with 96% +/- 4% in the perfused arm (P < 0.05). The maximum rate of onset was half that of the perfused arm. The difference in maximum neuromuscular block between arms was 17% +/- 7%, 5% +/- 5%, and 0% +/- 2% in th...Continue Reading

References

Feb 1, 1976·British Journal of Anaesthesia·V A GoatS A Feldman
Aug 1, 1992·Anesthesiology·J C MinD R Bevan
May 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F Donati
Jul 1, 1967·The Journal of Physiology·W D Paton, D R Waud
Oct 1, 1984·Anesthesia and Analgesia·F Donati, D R Bevan
Jul 1, 1993·Anesthesia and Analgesia·N G GoudsouzianJ Viby-Mogensen
Feb 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D R BevanF Donati
Mar 1, 1993·Clinical Pharmacology and Therapeutics·L P GariepyD R Bevan

❮ Previous
Next ❯

Citations

Feb 16, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B W BrandomM E Lloyd
Mar 24, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C Motamed, F Donati
Jun 21, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas M HemmerlingDavid Bracco
Jul 23, 2003·Anesthesia and Analgesia·Ryu KomatsuDaniel I Sessler
Jun 16, 2005·Acta Anaesthesiologica Scandinavica·Y LeykinA Gullo
Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Alejandro A Nava-OcampoJorge Salmerón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.