PMID: 1184958Jan 1, 1975Paper

[The ontogenetic development of pyramidal neurons in the hippocampus (CA1) of the rat].

Journal für Hirnforschung
H G Minkwitz, L Holz

Abstract

1. The development of pyramidal neurons of the hippocampus (CA1) of the albino rat was investigated by means of light-microscopy with GOLGI impregnation methods. The stages of age of the animals covered the period from the 15th prenatal to the 30th prematal day. Three and six months old rats were used for comparison. In addition some histological series were made by staining with hemalaun-eosine. 2. The formation of the apical, basal and side dendrites, the existence of common signs of growth (swellings, growth cones, sprouts) and the amount of spines were used for the estimation of neuronal changes. The development of the typical structure of the hippocampal region and of the pyramidal layer in the CA1-field was described. 3. The migration of neuronal elements to the pyramidal layer is finished around the time of birth, but lasts in the area dentata at least to the 8th postnatal day. The hippocampus shows a nearly mature figure in its hitology 15 days after birth. 4. Until the 19th embryonal day bipolare spongioblasts can be seen, but already one day before postmigratory neuroblasts are existent. During this period the division of matrix cells occurs and the migration of the neuroblasts is beginning. (early prenatal developmen...Continue Reading

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