PMID: 7528020Aug 1, 1994Paper

The ontogeny of insulin-like growth factor (IGF) and IGF-binding protein gene expression in the rat pancreas

Journal of Molecular Endocrinology
J HoggV K Han

Abstract

Insulin is important for optimal fetal and neonatal growth and development. Its continued availability is due, in part, to ongoing islet cell growth within the pancreas. IGFs and IGF-binding proteins (IGFBPs) have been implicated as paracrine regulators of islet cell growth within the developing pancreas. The purpose of this study was to determine whether the intact rat pancreas expresses mRNAs for IGF-I, IGF-II and IGFBPs, and how these might change with development. Liver was studied as a control tissue. Pancreas and liver were taken from fetal rats at 20-22 days of gestation, from postnatal rats at 1-21 days and from adult animals, and mRNAs for IGFs-I and -II and IGFBPs-1 to -6 were detected by Northern blot hybridization. The amount of IGF-II mRNA was greatest in the liver and pancreas of the fetal rat, and declined in both tissues during the neonatal period. Conversely, IGF-I mRNA levels were low but detectable in fetal life, and rose to adult levels within 2 weeks of birth. Both IGFBP-1 and IGFBP-2 mRNAs were present in fetal rat liver, increasing in amount over the first week of life, and declining in the adult. However, within the pancreas, IGFBP-1 mRNA was undetectable and IGFBP-2 mRNA was very low in the fetus and ne...Continue Reading

Citations

Feb 28, 2003·General and Comparative Endocrinology·G RadaelliB Funkenstein
Aug 29, 1998·Molecular and Cellular Endocrinology·M van KleffensS L Drop
Sep 12, 2002·Biochimica Et Biophysica Acta·Nancy M Dahms, Michael K Hancock
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