The ontogeny of mouse mammary gland responsiveness to ovarian steroid hormones.

Endocrinology
S Z Haslam

Abstract

An investigation was carried out to define the ontogeny of normal mouse mammary gland responsiveness to the proliferative effects of estrogen (E) and/or progesterone (P). Since hormone receptors for both estrogen (ER) and progesterone (PgR) are present in both epithelial and stromal cells, we have investigated how the effects of E and P are related to the presence of receptor activity in the epithelium and stroma. Intact or ovariectomized mice, between 3 days and 10 weeks of age, were used to study the effects of E and/or P on DNA synthesis, as determined by DNA histoautoradiography; the cellular distribution of ER and PgR was investigated by steroid autoradiography. The results indicate that the mammary gland sequentially acquires the ability to respond to the stimulatory effects of E and/or P. In the early postnatal period (3-14 days) neither hormone was effective. Both epithelial and stromal cells first became responsive to E at 3-4 weeks of age. Estrogen receptors were first detected in stromal cells at 5 days of age and in epithelial cells at 2 weeks of age. Thus, the acquisition of estrogen responsiveness did not appear to be tightly coupled to the presence of ER in either epithelial or stromal cells. In contrast, respons...Continue Reading

Citations

Jan 1, 1996·Breast Cancer Research and Treatment·M M Fluck, S Z Haslam
Jul 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·S Z Haslam, K A Nummy
Aug 27, 2010·Cold Spring Harbor Perspectives in Biology·Cathrin Brisken, Bert O'Malley
Jan 17, 2008·Critical Reviews in Eukaryotic Gene Expression·Anastasia KariaginaSandra Z Haslam
Mar 5, 2014·Disease Markers·Bruna Karina Banin HirataMaria Angelica Ehara Watanabe
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·W S ShimM H Jeng
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SajiJ A Gustafsson
Dec 3, 2013·Pharmacology & Therapeutics·Todd P Knutson, Carol A Lange
Sep 1, 1992·Journal of Cellular Physiology·S Z HaslamK A Nummy
Apr 23, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Sarah J SantosSandra Z Haslam
Sep 13, 2015·Journal of Mammary Gland Biology and Neoplasia·Corinne A BoulangerGilbert H Smith
Oct 3, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Laura N VandenbergAna M Soto
Mar 17, 1997·Biochemical and Biophysical Research Communications·J BarlowK Plaut
Oct 23, 2012·The Lancet Oncology·Kara Britt
Nov 12, 2016·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jennie G NollFrank W Putnam
Apr 11, 2018·The Journal of Endocrinology·Genevieve V DallKara L Britt
Sep 1, 1999·British Journal of Cancer·L Hilakivi-ClarkeR Clarke
Jul 22, 1998·Molecular and Cellular Biology·P Y DesprezJ Campisi
Aug 4, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G BerclazA C Andres
Aug 4, 2021·Reproductive Toxicology·Thalles Fernando Rocha RuizEllen Cristina Rivas Leonel

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