PMID: 9552372Jan 1, 1995Paper

The oocyte metaphase arrest

Progress in Cell Cycle Research
P Colas, P Guerrier

Abstract

Usually, oocyte meiosis reinitiation appears as a two step process during which release from the prophase block is followed by a second arrest in metaphase I or II. In this review, we will examine the mechanisms required to maintain the metaphase arrest and stabilize MPF activity at this stage. Then, we will analyse the processes required to exit from the metaphase block. These may drive the cells forward to the metaphase-anaphase transition, as a result of fertilization, activation or protein synthesis inhibition. Instead, inhibiting protein phosphorylation drives the oocyte back to interphase. All these treatments result in derepression of DNA synthesis.

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

© 2022 Meta ULC. All rights reserved