The Opioid-Addicted Tetrapartite Synapse

Biological Psychiatry
Anna KruyerPeter W Kalivas

Abstract

Opioid administration in preclinical models induces long-lasting adaptations in reward and habit circuitry. The latest research demonstrates that in the nucleus accumbens, opioid-induced excitatory synaptic plasticity involves presynaptic and postsynaptic elements as well as adjacent astroglial processes and the perisynaptic extracellular matrix. We outline opioid-induced modifications within each component of the tetrapartite synapse and provide a neurobiological perspective on how these adaptations converge to produce addiction-related behaviors in rodent models. By incorporating changes observed at each of the excitatory synaptic compartments into a unified framework of opioid-induced glutamate dysregulation, we highlight new avenues for restoring synaptic homeostasis that might limit opioid craving and relapse vulnerability.

Citations

Feb 23, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emilia M LefevrePatrick E Rothwell
Aug 11, 2020·Drugs·Reda M Chalhoub, Peter W Kalivas
Nov 8, 2020·The European Journal of Neuroscience·Bethania Mongi-BragatoLiliana M Cancela
Dec 23, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jerome A J BeckerJulie Le Merrer
May 8, 2021·Biological Psychiatry·Alexander K Zinsmaier, Yan Dong
Jan 10, 2021·Journal of Neurochemistry·Rusty W NallAna-Clara Bobadilla
Nov 16, 2021·Frontiers in Behavioral Neuroscience·Kelsey M VollmerJames M Otis

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