The opposed influences of beta-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs

D HilgemannH J Mensing


The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong beta-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with new method for recording continuous frequency-force loops are presented.


Aug 1, 1976·The Journal of Physiology·R W Tsien, R Weingart
Jan 21, 1977·European Journal of Pharmacology·S G McKenzieH P Bär
Jan 21, 1977·European Journal of Pharmacology·D ReinhardtH J Schümann
Jan 1, 1977·The Journal of Physiology·H Reuter, H Scholz
Dec 30, 1971·Annals of the New York Academy of Sciences·G A Robison, E W Sutherland
Jul 1, 1965·Journal of Applied Physiology·J R Blinks

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