The opposite effects of nitric oxide donor, S-nitrosoglutathione, on myocardial ischaemia/reperfusion injury in diabetic and non-diabetic mice

Clinical and Experimental Pharmacology & Physiology
Yi LiuL Tao

Abstract

Nitric oxide is a potent anti-apoptotic and cardioprotective molecule in healthy animals. However, recent study demonstrates that overexpression of eNOS exacerbates the liver injury in diabetic animals. whether diabetes may also alter NO's biologic activity in ischaemic/reperfused heart remains unknown. The present experiment was designed to determine whether the nitric oxide donor, S-nitrosoglutathione, may exert different effects on diabetic and non-diabetic myocardial ischaemia/reperfusion (MI/R) injury. Diabetic state was induced in mice by multiple intraperitoneal injections of low-dose streptozotocin (STZ). The control or diabetic mice were subjected to 30 minutes ischaemia and 3 or 24 hours reperfusion. At 10 minutes before reperfusion, diabetic and non-diabetic mice were received an intraperitoneal injection of S-nitrosoglutathione (GSNO, a nitric oxide donor, 1 μmol/kg). GSNO attenuated MI/R injury in non-diabetic mice, as measured by improved cardiac function, reduced infarct size and decreased cardiomyocyte apoptosis. In contrast, GSNO failed to attenuate but, rather, aggravated the MI/R injury in diabetic mice. Mechanically, the diabetic heart exhibited an increased nitrative/oxidative stress level, as measured by p...Continue Reading

References

Feb 17, 1998·Cardiovascular Research·X L MaH Ischiropoulos
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·X L MaM Feelisch
Nov 6, 2010·Cardiovascular Research·Qiujun YuXin L Ma
Jul 26, 2012·American Journal of Physiology. Endocrinology and Metabolism·Yi LiuLing Tao
Apr 26, 2013·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Z YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Feb 4, 2014·Journal of Molecular and Cellular Cardiology·Mark J KohrElizabeth Murphy
Mar 7, 2014·American Journal of Physiology. Endocrinology and Metabolism·Yanbin SongLing Tao
Jan 1, 2015·Journal of Diabetes and Metabolic Disorders·Yousef RasmiEhsan Saboory
Nov 15, 2016·The Journal of Clinical Investigation·Rongli ZhangJonathan S Stamler
Nov 15, 2016·The Journal of Clinical Investigation·Claude A Piantadosi
Nov 22, 2016·Journal of Molecular and Cellular Cardiology·C FarahC Reboul
Feb 18, 2017·Circulation Research·Ulrich FörstermannHuige Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.