The optimal age of vaccination against dengue in Brazil based on serotype-specific forces of infection derived from serological data.

Mathematical Medicine and Biology : a Journal of the IMA
Sandra B MaierDavid Greenhalgh

Abstract

In this paper, we study a single serotype transmission model of dengue to determine the optimal vaccination age for Dengvaxia. The transmission dynamics are modelled with an age-dependent force of infection. The force of infection for each serotype is derived from the serological profile of dengue in Brazil without serotype distinction and from serotype-specific reported cases. The risk due to an infection is measured by the probability of requiring hospitalization based on Brazilian Ministry of Health data. The optimal vaccination age is determined for any number and combination of the four distinct dengue virus serotypes DENv1-4. The lifetime expected risk is adapted to include antibody dependent enhancement (ADE) and permanent cross-immunity after two heterologous infections. The risk is assumed to be serostatus-dependent. The optimal vaccination age is computed for constant, serostatus-specific vaccine efficacies. Additionally, the vaccination age is restricted to conform to the licence of Dengvaxia in Brazil and the achievable and minimal lifetime expected risks are compared. The optimal vaccination age obtained for the risk of hospitalization varies significantly with the assumptions relating to ADE and cross-immunity. Ri...Continue Reading

References

Aug 1, 1990·Statistics in Medicine·C P Farrington
Jan 1, 1984·IMA Journal of Mathematics Applied in Medicine and Biology·R M Anderson, R M May
Mar 24, 2006·Tropical Medicine & International Health : TM & IH·C FavierP Tsouris
Dec 19, 2007·Seminars in Diagnostic Pathology·Anthony S-Y LeongPongsak Wannakrairot
Sep 16, 2009·Annals of the New York Academy of Sciences·Scott B Halstead
Nov 17, 2009·The Journal of Infectious Diseases·Tran Nguyen Bich ChauCameron P Simmons
Apr 21, 2010·FEMS Immunology and Medical Microbiology·Amita Jain, Umesh C Chaturvedi
Aug 5, 2011·The American Journal of Tropical Medicine and Hygiene·Willem G van PanhuisDerek A T Cummings
Jun 8, 2012·Paediatrics and International Child Health·Roberto Tapia-ConyerPierre Burciaga-Zúñiga
Oct 4, 2012·Revista Do Instituto De Medicina Tropical De São Paulo·Marcos AmakuEduardo Massad
Apr 9, 2013·Nature·Samir BhattSimon I Hay
Jul 28, 2015·The New England Journal of Medicine·Sri Rezeki HadinegoroUNKNOWN CYD-TDV Dengue Vaccine Working Group
Feb 14, 2016·Vaccine·Scott B Halstead, Philip K Russell
Jan 1, 2015·Journal of Market Access & Health Policy
Aug 2, 2016·The Lancet Infectious Diseases·Maíra AguiarScott B Halstead
Aug 9, 2016·The Journal of Infectious Diseases·Scott B Halstead
Aug 9, 2016·The Journal of Infectious Diseases·Annelies Wilder-SmithTerry Nolan
Sep 10, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN FIGO Working Group On Challenges In Care Of Mothers And Infants During Labour And Delivery
Nov 8, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Mânlio Tasso de Oliveira MotaMaurício Lacerda Nogueira
Dec 22, 2016·PLoS Neglected Tropical Diseases·Maíra AguiarScott B Halstead
Jun 18, 2017·Vaccine·Ruth Aralí Martínez-VegaJosé Ramos-Castañeda
Jun 29, 2017·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Valdelaine Etelvina Miranda de AraújoMariângela Carneiro
Jul 26, 2017·PLoS Neglected Tropical Diseases·Panayiota KotsakioziJeffrey R Powell
Aug 20, 2017·BMJ : British Medical Journal·Abi Rimmer
Sep 25, 2017·Mathematical Biosciences·Sandra B MaierDavid Greenhalgh
Nov 1, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maíra Aguiar, Nico Stollenwerk
Dec 26, 2017·The Lancet Infectious Diseases·Maíra Aguiar, Nico Stollenwerk
Mar 23, 2019·BMC Public Health·Priscila Conrado Guerra NunesFlávia Barreto Dos Santos

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