The optimal cutoff value of glycated hemoglobin for detection of diabetic retinopathy

Diabetes & Metabolism Journal
Jung Min Kim, Dong-Jun Kim

Abstract

With standardization of measurement of glycated hemoglobin (A1C), the International Expert Committee Report in 2009 and the American Diabetes Association in 2010 recommended incorporating A1C ≥6.5% into the previous diagnostic criteria using fasting plasma glucose and/or 2-hour plasma glucose. Whereas the association of A1C with cardiovascular diseases and other diabetic microvascular complications was linear without evidence of a distinct threshold, several studies suggested a threshold value for A1C in diabetic retinopathy (DR). In studies about the optimal cutoff value for A1C in DR, the A1C values range from 5.2% to 7.8%. There are several possible reasons why these values for DR differ so widely (differences in the definition and/or methods for DR, variation in statistical methods, differences in study population, differences in exclusion criteria, and difference in methods for measuring A1C). With these wide variations in the study method, drawing a conclusive cutoff value for A1C in DR is impossible. In published studies, the cutoff values for moderate or severe DR were higher than those for any or mild DR (6.4% to 7.0% vs. 5.5% to 6.5%).

References

May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·K H GabbayP M Gallop
Jun 1, 1976·The Journal of Clinical Investigation·H F BunnP M Gallop
Aug 19, 1976·The New England Journal of Medicine·R J KoenigA Cerami
Oct 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Rahbar
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Apr 1, 1996·QJM : Monthly Journal of the Association of Physicians·E S KilpatrickM Small
Jul 24, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·A FinkeJ O Jeppsson
Aug 30, 2000·Diabetes Research and Clinical Practice·C ItoH Sasaki
Oct 25, 2002·American Journal of Epidemiology·Diane E BildRussell P Tracy
Feb 14, 2003·Archives of Ophthalmology·Hendrik A van LeidenBettine C P Polak
May 20, 2003·Neuropsychologia·Ralph Axel MüllerEric Courchesne
Nov 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·W Garry John
Feb 8, 2005·Clinical Chemistry·William L RobertsRandie R Little
Apr 29, 2006·Diabetes Research and Clinical Practice·R J TappUNKNOWN AusDiab Study Group
May 31, 2007·Diabetes Care·William H HermanUNKNOWN Diabetes Prevention Program Research Group
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Oct 20, 2009·Diabetes Care·Caroline K KramerElizabeth Barrett-Connor
Nov 11, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·T Likhari, R Gama
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Jul 20, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·S A MostafaK Khunti
Oct 28, 2010·Diabetes Care·Stephen ColagiuriUNKNOWN DETECT-2 Collaboration Writing Group
Feb 16, 2011·Archives of Ophthalmology·Pascale MassinUNKNOWN DESIR (Data From an Epidemiological Study on the Insulin Resistance Syndrome) Study Group
Aug 8, 2012·Annals of Internal Medicine·Yusuke TsugawaChristina C Wee
Sep 11, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·W G John, UNKNOWN UK Department of Health Advisory Committee on Diabetes
Jan 29, 2013·Acta Diabetologica·Nam H ChoSung Hee Choi
Apr 2, 2013·Diabetes Research and Clinical Practice·Hyejin LeeBon-Jeong Ku

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