Abstract
The aim of the present study was to investigate the protective effects of ischemic preconditioning for different periods of time and to elucidate the optimal safe ischemic preconditioning time for renal ischemia-reperfusion (I/R) injury in mice. A total of 25 male C57BL/6 mice were randomly divided into 5 groups (sham, I/R, ischemic preconditioning [IP]-3, IP-5, and IP-7 groups), in which the kidney was preconditioned with IP of various durations and then subjected to I/R injury (the last 3 groups). To induce renal ischemia, the left renal pedicle was occluded with a nontraumatic microaneurysm clamp for 30 minutes followed by reperfusion for 24 hours. The effects of IP on renal I/R injury were evaluated in terms of renal function, tubular necrosis, apoptotic cell death and inflammatory cytokines. Results indicated that BUN and creatinine (Cr) levels increased significantly in the I/R group, but the elevations were significantly lower in IP groups, especially in the IP-5 group. Histological analysis revealed that kidney injury was markedly decreased in the IP-5 group compared with the I/R group, as evidenced by reduced renal necrosis/apoptosis. In addition, IP significantly inhibited gene expression of pro-inflammatory cytokines...Continue Reading
References
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·C HeurteauxM Lazdunski
Jan 1, 1995·Circulation Research·M B MitchellA Banerjee
May 6, 1996·Biochemical and Biophysical Research Communications·G HotterJ Roselló-Catafau
Apr 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C PeraltaJ Roselló-Catafau
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C PeraltaG Hotter
May 25, 2002·Kidney International·Joan TorrasJosep Ma Grinyó
Jan 31, 2006·Microsurgery·Andrea FerenczErzsbet Roth
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Jin Deok JooH Thomas Lee
Jan 16, 2007·Cell Biochemistry and Function·Su Hua JiangXiao Qiang Ding
Sep 15, 2007·The Journal of Clinical Investigation·Huiling WuSteven J Chadban
Oct 22, 2008·Basic Research in Cardiology·Hanne Støre Valeur, Guro Valen
Nov 18, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Wei Chao
Dec 23, 2008·Transplantation Proceedings·R P JiaJ G Zhu
Jun 24, 2009·American Journal of Nephrology·Xin ChenChangchun Cao
Feb 24, 2010·Nature Reviews. Nephrology·Anna GlubaJacek Rysz
Jul 14, 2010·Transplantation Proceedings·M LiuY Wu
Mar 6, 2012·PloS One·Kimberley E WeverMichiel Warlé
Sep 21, 2012·American Journal of Physiology. Renal Physiology·Qingqing Wei, Zheng Dong
Nov 23, 2012·Nephron. Experimental Nephrology·Tobias BerglerBernhard Banas
Aug 16, 2013·American Journal of Physiology. Renal Physiology·Takuya YoshidaNaoki Ikegaya
Feb 14, 2014·American Journal of Physiology. Renal Physiology·Hailin ZhaoDaqing Ma
Citations
Feb 7, 2020·Clinical and Experimental Pharmacology & Physiology·Heli XiangXiaoyan Wu
Feb 7, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Franka MessnerChristian Margreiter
Oct 1, 2019·Annals of Surgery·Michèle J de KokJan H Lindeman
Aug 15, 2019·Experimental and Therapeutic Medicine·Xian-Liang MengShi-Hua Sui
Dec 13, 2018·Neural Regeneration Research·Jun-Jie WangYan Yu
Jan 28, 2020·International Journal of Molecular Medicine·Makiko YamamotoAtsuhiro Sakamoto
Jan 1, 2021·Toxicology·Lei TianXiaohua Liu
May 15, 2021·International Journal of Nephrology·Farzaneh Karimi, Mehdi Nematbakhsh