The optimal extent of gastrectomy for middle-third gastric cancer: distal subtotal gastrectomy is superior to total gastrectomy in short-term effect without sacrificing long-term survival

BMC Cancer
Xin JiJia-Fu Ji

Abstract

The optimal extent of gastrectomy for middle-third gastric cancer remains controversial. In our study, the short-term effects and longer-term survival outcomes of distal subtotal gastrectomy and total gastrectomy are analysed to determine the optimal extent of gastrectomy for middle-third gastric cancer. We retrospectively collect and analyse clinicopathologic data and follow-up outcomes from a prospectively collected database at the Peking University Cancer Hospital. Patients with middle-third gastric adenocarcinoma who underwent curative resection are enrolled in our study. We collect data of 339 patients between January 2005 and October 2011. A total of 144 patients underwent distal subtotal gastrectomy, and 195 patients underwent total gastrectomy. Patients in the total gastrectomy group have longer operative duration (P < 0.001) and postoperative hospital stay (P = 0.001) than those in the distal subtotal gastrectomy group. In the total gastrectomy group, more lymph nodes are harvested (P < 0.001). Meanwhile, the rate of postoperative complications is lower in the distal subtotal gastrectomy group than in the total gastrectomy group (8% vs 15%, P = 0.047). Further analysis demonstrates that the rate of anastomosis leakage ...Continue Reading

References

May 22, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Toshifusa Nakajima
Nov 12, 2002·Surgical Oncology Clinics of North America·Hubert J SteinJörg R Siewert
Dec 29, 2004·Annals of Surgery·Bryan J DickenStewart M Hamilton
Sep 27, 2006·Current Problems in Surgery·Clancy J ClarkEugene Lin
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Jun 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemJ Zalcberg
Aug 28, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Manfred P LutzUNKNOWN First St Gallen EORTC Gastrointestinal Cancer Conference 2012 Expert Panel
Mar 22, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ana FerroNuno Lunet
Aug 16, 2014·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Y M GohS Paterson-Brown
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
May 10, 2016·Lancet·Eric Van CutsemHans Prenen
Jun 28, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association

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Citations

Oct 28, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K LudwigJ Bernhardt
Oct 18, 2018·Yonsei Medical Journal·Seok Jun KimKyung Hee Chun
Mar 24, 2021·Revista de gastroenterología de México·O R Paredes-TorresE Payet-Meza
Feb 17, 2021·Journal of Gastrointestinal Cancer·Aarefeh Jafarzadeh KohnelooHojjat Zeraati
May 11, 2021·World Journal of Gastroenterology : WJG·Jan GrosekAleš Tomažič
Aug 8, 2021·Revista De Gastroenterología De México·O R Paredes-TorresE Payet-Meza

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Methods Mentioned

BETA
surgical resection
biopsy
dissection

Software Mentioned

SPSS Statistics

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