The optimal management of hairy cell leukaemia

Drugs
R GollardA Saven

Abstract

Hairy cell leukaemia is an uncommon B cell chronic lymphoproliferative disorder characterised by circulating lymphocytes displaying prominent cytoplasmic projections. Therapy is initiated for severe cytopenias or recurrent infections. Splenectomy, the first standard treatment, is now less commonly used as primary treatment. Interferon-alpha (IFN alpha) induces partial responses in most patients but complete responses in only a few. Adverse effects from IFN alpha are common but not life-threatening. The ability of two newer purine analogues, pentostatin (2'-deoxycoformycin) and cladribine (2-chlorodeoxyadenosine), to induce long-lasting complete remissions in the majority of patients has revolutionised the treatment of this disease. Cladribine is emerging as the treatment of choice because of its favourable toxicity profile, brief duration of treatment, high percentage of unmaintained complete remissions and low incidence of relapse.

Citations

Mar 20, 1999·Journal of Surgical Oncology·R M Walsh, B T Heniford
Feb 8, 2003·The Lancet Oncology·Ulrich MeyIngo Schmidt-Wolf
May 25, 1999·Periodontology 2000·S A Sternberg, M Gordon
Apr 1, 1997·Leukemia & Lymphoma·M Blasińska-MorawiecH Urbańska-Ryś
Aug 2, 2006·The Oncologist·Sam O Wanko, Carlos de Castro

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