PMID: 3755641Jul 1, 1986Paper

The optimal priming dose for atracurium

Canadian Anaesthetists' Society Journal
M NaguibG H Absood

Abstract

To determine the optimal priming dose for administration in divided doses, atracurium was given to 77 patients either in a single dose of 0.5 mg X kg-1 or in an initial dose of 0.04, 0.05, 0.06, 0.07, 0.08 or 0.09 mg X kg-1, followed three minutes later by the remainder of the 0.5 mg X kg-1 dose. Patients were anaesthetized throughout the study. When atracurium was given as a single bolus of 0.5 mg X kg-1, the mean time to complete neuromuscular block was 141.5 seconds. Administration in divided doses accelerated the onset time (p less than 0.01), that is the time from the intubating dose to the complete suppression of train-of-four (TOF) response. The TOF ratio decreased slightly but statistically significantly following the priming doses. When the priming dose was 0.05 mg X kg-1, the mean onset time was 70.9 seconds and priming with larger doses did not add any further advantage. It is concluded that 0.05 mg X kg-1 appears to be the optimal priming dose for the administration of atracurium in divided doses. When 0.05 mg X kg-1 is given three minutes before the intubating dose, tracheal intubation can be accomplished in less than 90 seconds.

References

Apr 1, 1985·Anesthesiology·S SchwarzF F Foldes
Apr 1, 1986·Masui. The Japanese journal of anesthesiology·T AokiF F Foldes
Mar 1, 1986·Canadian Anaesthetists' Society Journal·M NaguibG H Absood
Jan 1, 1985·Canadian Anaesthetists' Society Journal·W G DohertyD R Bevan
Apr 1, 1985·Anesthesiology·R D Miller
Jul 1, 1967·The Journal of Physiology·W D Paton, D R Waud
Oct 1, 1980·Acta Anaesthesiologica Scandinavica·P Howardy-HansenJ Viby-Mogensen
Sep 1, 1980·Anesthesia and Analgesia·T L Rao, H K Jacobs

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Citations

Jan 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F Donati
Jan 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Naguib, M Abdulatif
May 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C A TrépanierL Lacerte
Oct 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Naguib
Aug 12, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K F KohV Esuvaranathan
May 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Sosis
Mar 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M E McLeod, J Lerman
May 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F Donati
Nov 1, 1986·Canadian Anaesthetists' Society Journal·M Abdulatif, M Naguib
Feb 1, 1991·Anaesthesia and Intensive Care·N M GibbsD E Martin

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