The optimal setting of complex fractionated atrial electrogram software in substrate ablation for atrial fibrillation

Journal of Arrhythmia
Fuminori NaminoTeruto Hashiguchi

Abstract

Complex fractionated atrial electrogram (CFAE)-targeted catheter ablation (CFAE ablation) requires a high rate of atrial fibrillation (AF) termination to provide good outcomes. We determined the optimal settings of CFAE software. In our 430 consecutive patients, AF was terminated in 97 (234/242) and 79% (149/188) of patients with paroxysmal and persistent AF, respectively, by CFAE ablation combined with (31%) or without (69%) pulmonary vein isolation, occasionally with nifekalant infusion. We analyzed 109 consecutive patients who underwent CFAE ablation to determine the optimal settings for comparing subjective versus objective decisions by the CFAE software on CARTO3. We compared three settings: the default setting (0.05-0.15 mV, 50-120 ms) and two modified settings (#1: 0.05-0.30 mV, 40-70 ms, #2: 0.05-0.13 mV, 10-20 ms). We retrospectively analyzed 11,425 points during left atrial mapping before ablation and 10,306 points that were subjectively detected and ablated as CFAE points. An interval confidence level ≥6 denoted a site with CFAE. With the default setting, the accuracy, sensitivity, specificity, positive productive value, and negative productive values were 67, 42, 77, 48, and 73%, respectively. With modified setting ...Continue Reading

References

Sep 3, 1998·The New England Journal of Medicine·M HaïssaguerreJ Clémenty
Aug 6, 2003·Circulation·Giuseppe StabileAntonio De Simone
Jun 3, 2004·Journal of the American College of Cardiology·Koonlawee NademaneeTachapong Ngarmukos
Jun 2, 2005·JAMA : the Journal of the American Medical Association·Oussama M WazniAndrea Natale
Nov 24, 2005·Journal of Cardiovascular Electrophysiology·Michel HaïssaguerrePierre Jaïs
Feb 26, 2008·Journal of the American College of Cardiology·Koonlawee NademaneeTachapong Ngarmukos
Sep 2, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Heidi Luise EstnerIsabel Deisenhofer
Mar 31, 2010·Journal of cardiology·Michiharu SengaMasaaki Ito

❮ Previous
Next ❯

Citations

May 30, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fuminori NaminoIkuro Maruyama
Nov 22, 2018·Frontiers in Physiology·Ghassen ChenitiFrederic Sacher
Apr 23, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Issei YoshimotoMitsuru Ohishi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.