The optimal time of day for statin administration: a review of current evidence

Current Opinion in Lipidology
Kamal Awad, Maciej Banach

Abstract

In humans, cholesterol biosynthesis varies diurnally, reaching its peak at night. Therefore, choosing the time of statin administration is critical because of their different half-lives. Dose timing becomes more important in patients with polypharmacy because it might affect their adherence to the statin therapy. Herein, we narratively summarized the available clinical studies (n = 17) and meta-analyses (n = 2) that compared the morning with the evening dose of statins in terms of safety and efficacy, with special focus on their low-density lipoprotein-lowering effects. We also explained the difference in efficacy results in case of short-acting compared with the long-acting statins and highlighted how flexibility in choosing the time of statin administration is important for better adherence. The current limited evidence suggests that short-acting statins should be given in the evening whereas long-acting statins could be given at any time of the day with allowing more patient-based choice (of timing) for better adherence. Lager RCTs with longer durations are recommended to extend and confirm the current evidence.

References

Jul 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y SaitoY Goto
Sep 1, 1984·The Journal of Clinical Investigation·T S ParkerP J De Schepper
Jan 1, 1993·European Journal of Clinical Pharmacology·W KruseG Schlierf
Dec 21, 2000·Journal of Clinical Pharmacy and Therapeutics·D N KiortsisG Turpin
Oct 4, 2003·BMJ : British Medical Journal·Alan WallaceGreg Rubin
Dec 14, 2004·International Journal of Clinical Practice·G De Angelis
Jan 22, 2005·Fundamental & Clinical Pharmacology·Michael Schachter
May 25, 2005·Archives of Internal Medicine·Richard H ChapmanJ Sanford Schwartz
Nov 24, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Roda PlakogiannisDavid Taft
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Simon ThomUNKNOWN UMPIRE Collaborative Group
Sep 28, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Piia K RannanheimoMaarit Jaana Korhonen
Aug 28, 2016·European Heart Journal·Alberico L CatapanoUNKNOWN ESC Scientific Document Group
Oct 27, 2016·JAMA : the Journal of the American Medical Association·Kirsten Bibbins-Domingo
Jul 26, 2017·Cardiovascular Drugs and Therapy·Kamal AwadUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group

❮ Previous
Next ❯

Citations

Nov 28, 2019·Cardiovascular Drugs and Therapy·Veronica AzemawahMehrnoosh Hashemzadeh
Mar 3, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Danyi LuBaojian Wu
Jul 16, 2020·BMC Complementary Medicine and Therapies·Gul AmbreenZara Naz
Oct 8, 2020·Clinical Pharmacology and Therapeutics·James C WaltonRandy J Nelson
Feb 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Niki KatsikiUNKNOWN International Lipid Expert Panel (ILEP)

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.