The optimum temperature for the heat therapy for meibomian gland dysfunction

The Ocular Surface
Douglas Borchman

Abstract

Numerous devices have been developed to warm the eyelid as a therapy for Meibomian gland dysfunction. The optimum temperature for such therapy was determined. Meibum lipid disorder versus temperature was calculated from previously published phase transition parameters measured using infrared spectroscopy. Phase transitions parameters were calculated from meibum obtained from donors with Meibomian gland dysfunction (MMGD), donors who were susceptible to dry eye after hematopoietic stem cell transplantations (MHSCT) and meibum from donors without dry eye (Mn). Heating Mn to 40 °C increases the lipid disorder by 20.4%-90%. Heating the meibum another 4° increases the disorder to 95%. MMGD is 73.2% disordered with no heating. Heating MMGD to 41.5 °C increases the disorder by 26.8%-90% disordered. Heating MMGD another 5.1 °C increases the disorder to 95%. As MHSCT is much more ordered, 56.9% disordered compared with Mn and MMGD, a higher temperature above safety limits, 52 and 59 °C is need to disorder MHSCT to 90 and 95% disorder. Heating the eye lid above the phase transition temperature of meibum increases the disorder of meibum lipid which could ameliorate dry eye symptoms. The optimum temperature for disordering Mn and MMGD to 9...Continue Reading

Citations

Jul 3, 2019·Antibiotics·Azadeh Tavakoli, Judith Louise Flanagan
Aug 2, 2019·Cornea·Douglas BorchmanAparna Ramasubramanian
Jul 25, 2019·International Journal of Molecular Sciences·Georgi As GeorgievNorihiko Yokoi
Aug 25, 2019·Journal of Clinical Medicine·Yu-Kai KuoChing-Li Tseng
Jan 17, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Reiko Arita, Shima Fukuoka
Jun 20, 2020·Journal of Lipid Research·Douglas Borchman
Feb 9, 2021·Journal of Lipid Research·Douglas Borchman
Feb 12, 2020·Biochemistry and Biophysics Reports·Zofia A Hetman, Douglas Borchman
May 10, 2021·Chemistry and Physics of Lipids·Anthony EwurumDouglas Borchman
May 20, 2021·Current Opinion in Ophthalmology·Rhiya MittalAnat Galor
Aug 11, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jindong HuXinquan Liu
Nov 10, 2021·Acta Ophthalmologica·Morten Schjerven MagnoTor P Utheim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.