The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
E A Romero-SandovalJ F Herrero

Abstract

To study the involvement of all-trans retinoic acid (ATRA) in the development and maintenance of inflammatory pain. Adult male Wistar rats and murine neuro2a and human SH-SY5Y neuroblastoma cells. Soft-tissue inflammation was induced by the intraplantar administration of 100 microl of carrageenan lambda. The oral treatment with either ATRA or vehicle lasted for seven days and consisted in a dose of 15 mg/kg the first two days and a dose of 10 mg/kg the following five days. Neuroblastoma cells were incubated for 16 h with ATRA. Rats were tested twice daily for intensity and evolution of withdrawal reflexes evoked by mechanical and thermal stimulation. The expression of COX enzymes was studied in spinal cords and neuroblastoma cells by western blot. The animals treated with ATRA showed a significantly more intense development of mechanical allodynia (p < 0.01), mechanical hyperalgesia (p < 0.01), thermal hyperalgesia (p < 0.001) and reduction of threshold for mechanical (29 +/- 4 vs. 60 +/- 6 mN, p < 0.001) and thermal stimulation (12 +/- 0.3 vs. 8.4 +/- 0.3 s, p < 0.001) than control animals. Recovery to mechanical baseline data was slower in animals treated with ATRA, the main difference was observed in the test carried out on ...Continue Reading

Citations

Aug 9, 2013·The Journal of Clinical Investigation·Shijin YinHongzhen Hu
Nov 30, 2013·Progress in Lipid Research·Marco SisignanoKlaus Scholich
Mar 23, 2010·European Journal of Pharmacology·Kenji SakamotoKunio Ishii
Dec 7, 2013·British Journal of Pharmacology·Shijin YinHongzhen Hu
May 10, 2015·Journal of Pharmacological and Toxicological Methods·Andrzej WróbelTomasz Rechberger
Sep 27, 2007·CNS Drug Reviews·E Alfonso Romero-SandovalJuan F Herrero
Dec 13, 2006·Pharmacology·Matilde AliqueMasanori Kitamura
Mar 15, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Enas Ahmed HamedMohamed Abdullah Balfas

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