The Oral-Lung Axis: The Impact of Oral Health on Lung Health

Respiratory Care
Nathaniel T GaeckleGerard J Criner

Abstract

Poor oral health has long been recognized as a clinical risk factor for developing lung infections. Recent data using culture-independent techniques assessing the microbiome in healthy subjects have demonstrated that chronic microaspiration establishes a very similar microbial community between the mouth and lung, suggesting these 2 anatomic regions are closely intertwined. Dental disease is driven and aided by a dysbiosis in the oral microbiome, and evidence is mounting that implicates the microbiome in a variety of lung diseases including asthma, COPD, pulmonary fibrosis, and pneumonia. This review describes common dental conditions and potential mechanisms by which poor oral health may contribute to lung disease. We also review the current literature drawing associations between poor oral health and lung disease.

Citations

Oct 13, 2020·Frontiers in Medicine·Keshav Raj PaudelPhilip M Hansbro
Dec 15, 2020·Journal of Oral Microbiology·Zhenting XiangAurea Simon-Soro
Apr 30, 2021·Journal of Medical Virology·Dominique KangErik Kulstad
May 29, 2021·ERJ Open Research·Toru TakeshitaYoshihisa Yamashita

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