The oral microbiome in oral lichen planus during a 1-year randomized clinical trial

Oral Diseases
C Kragelund, M K Keller

Abstract

Several recent studies have investigated the oral bacteriome in oral lichen planus (OLP), but longitudinal changes in microbiome have not been investigated. To study the bacteriome and mycobiome in OLP over a 1-year period and the impact of topical treatment. Samples from 22 symptomatic OLP patients from a double-blinded, randomized intervention study were collected over a 1-year course at five visits. Bacterial and fungal abundances were investigated through lesional cytobrush (CB) and full mouthwash (MW). Initially, all patients received conventional (antimycotic or steroid) and probiotic or placebo treatment. The microbial composition differed between the MW and CB samples. During the study period, the microbial composition was individual, with pronounced variability between visits. Patients grouped according to initial conventional treatment. During the study period, unidirectional change in the bacteriome was seen in the antimycotic group, whereas the mycobiome was stable. Malassezia restricta was the most abundant fungus. The microbial composition of MW and CB differs in OLP. CB composition is less influenced by conventional and probiotic intervention. Initial antimycotic treatment influenced the bacteriome during the 1-y...Continue Reading

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Citations

May 24, 2019·Pathogens·Wibke KrügerMaria Joanna Niemiec
Aug 10, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Duo-Na XiaGang Zhou
Dec 16, 2020·Journal de mycologie médicale·Bibi KhadijaRani Faryal
Nov 12, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Heidi Tuominen, Jaana Rautava
Oct 21, 2021·Clinical and Experimental Dermatology·M KarimovaJ F Setterfield

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