The oral mucosa: A barrier site participating in tissue-specific and systemic immunity

Oral Diseases
Niki M Moutsopoulos, H M Moutsopoulos

Abstract

In the oral cavity, the immune system is constantly exposed to unique tissue-specific signals, including a rich community of commensal microbes and their metabolites, continuous tissue damage from mastication, and antigens from food and airborne particles. How this unique combination of signals participates in the training of specialized immunity at this site is not well understood, yet imbalance of local responses is linked to tissue-specific disease susceptibilities with the prototypic disease being periodontitis. However, the oral mucosa is also well recognized as a site where systemic inflammatory and autoimmune diseases often manifest, indicating that systemic immune deregulation is reflected in the function of the oral immune system. This commentary will discuss both aspects of compartmentalized and systemic immunity at the oral mucosa.

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Citations

Dec 1, 2018·Journal of Immunoassay & Immunochemistry·Haseeb Ahsan
Nov 5, 2019·Oral Diseases·Gabriela Anaya-Saavedra
Dec 6, 2019·Science Translational Medicine·Amanda S Woodward DavisMartin Prlic
Aug 30, 2019·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Juan Pablo Loyola-RodriguezOscar Sanchez-Adame
Dec 18, 2020·Frontiers in Immunology·Alberto VázquezAngeles Vicente
Feb 11, 2021·Cells·Natalia KurilenkoEkaterina K Koltsova
Mar 11, 2021·Periodontology 2000·Gary G Borisy, Alex M Valm
Mar 16, 2021·Frontiers in Immunology·Javier Sanchez-SolaresCristina Gomez-Casado
Jun 16, 2021·Cell·Drake Winslow WilliamsNiki Maria Moutsopoulos
Dec 4, 2021·Frontiers in Immunology·Eliana Perez RoseroShokrollah Elahi
Jul 28, 2020·Current Stem Cell Research & Therapy·Wang GongQianming Chen

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